Cancer Biology and the Nuclear Envelope : Recent Advances May Elucidate Past Paradoxes

Lingua: inglese

Editore: Springer, 2014

1489980318 / 9781489980311

Serie: Libro 160 di 544 - Advances in Experimental Medicine and Biology

Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

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Condizione: Nuovo

EUR 241,76

EUR 42,32 spedizione 
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Descrizione dell’articolo da parte del venditore

Druck auf Anfrage Neuware - Printed after ordering - 'Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.'.…

Codice articolo 9781489980311

Titolo
Cancer Biology and the Nuclear Envelope : Recent Advances May Elucidate Past Paradoxes
Autore
Jose I. De Las Heras
Editore
Springer
Anno di pubblicazione
2014
Condizione
Neu
Rilegatura
Buch
Lingua
inglese
ISBN 10
1489980318
ISBN 13
9781489980311
Peso dell'articolo
1046 grammi
Dimensioni
241x160x39 mm
Serie
Libro 160 di 544: Advances in Experimental Medicine and Biology

AHA-BUCH GmbH

Einbeck, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 7 a 10 giorni lavorativiDa 5 a 7 giorni lavorativi
Primo articoloEUR 42,32EUR 57,55
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