Carnitine Today

Lingua: inglese

Editore: Springer, Humana Mai 2014, 2014

146137751X / 9781461377511

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This item is printed on demand - Print on Demand Titel. Neuware -Inhaltsangabe1. The Role of Carnitine in Cell Metabolism.- A Century of Carnitine Research.- Biosynthesis, Uptake and Excretion.- Carnitine Acyltransferases.- Fatty Acid Oxidation in Liver.- Fatty Acid Oxidation in Heart.- Carnitine in Insulin Secretion.- Perspectives.- 2. Molecular Biology of Carnitine Palmitoyltransferases and Role of Carnitine in Gene Transcription.- Mitochondrial CPTs.- Peroxisomal CPTs.- Microsomal CPTs.- Nuclear CPTs.- A Role for Carnitine in the Transcriptional Regulation.- Perspectives.- 3. Carnitine and Myocardial Glucose Metabolism.- Review of the Literature.- Conclusions.- 4. Carnitine and Mitochondrial Dysfunction.- Mitochondrial Function and Dysfunction.- Carnitine-Related Mitochondrial Disorders.- Carnitine, CoA and Mitochondrial Function.- Carnitine and Mitochondrial Alterations Induced by Anoxia.- 5. Effect of L-Carnitine on Fas-Induced Apoptosis and Sphingomyelinase Activity in Human T Cell Lines.- Materials and Methods.- Effect of Camitine on Fas-Induced Apoptosis in Hut78 and U937 Cells.- Effect of L-Carnitine on Fas Crosslinking-Induced Ceramide Generation in Hut78 and U937 Cells.- Effect of L-Carnitine on Fas Crosslinking-Induced Acidic and Neutral SMases.- Effects of L-Carnitine on Purified Acidic and Neutral SMases in Vitro.- Discussion.- 6. Carnitine Deficiency: Primary and Secondary Syndromes.- Carnitine Metabolism.- Functions of Carnitine.- Carnitine Deficiency in Humans.- Primary Carnitine Deficiencies.- Secondary Carnitine Deficiencies.- Myocardial Diseases and Secondary Carnitine Deficiency.- Diabetes and Secondary Carnitine Deficiency.- Idiopathic Inflammatory Myopathies.- Drugs and Carnitine Deficiency.- 7. Carnitine Against Ischemia and Lipopolysaccharide Toxicity.- L-Carnitine in the Treatment of Ischemic Muscles.- Summary.- 8. Carnitine and Derivatives in Experimental Infections.- Results of Murine Studies.- Results of Rat Studies.- Discussion.- 9. Involvement of Carnitine in Reye's and Reye-Like Syndromes.- Definition of Reye's and Reye-Like Syndromes.- Pathological Manifestation of RS and RLS.- Involvement of Carnitine.- Carnitine Treatment in RS and RLS.- 10. Fatigue Syndrome.- Summary.- Acylcarnitine (ACR) Deficiency in CFS.- ACR Metabolism in Mammals.- The Uptake of ACR in the Brain of Rhesus Monkeys and Humans.- Hypothesis: the Role of ACR in the Etiology of CFS.- Acetyl-L-Camitine Treatment for Patients with CFS.- 11. L-Carnitine, a Modulator of Immunometabolic Homeostasis in Subjects Infected with the Human Immunodeficiency Virus.- Immunomodulating Properties of L-Carnitine.- Serum and Cellular Carnitine Deficiency in HIV-Infected Subjects.- Carnitine Deficiency and Mitochondrial Toxicity of Nucleoside Analogs.- Etiology of Carnitine Deficiency in AIDS.- Impact of L-Carnitine Therapy on Lymphocyte Mitogen Responsiveness and Carnitine Cellular Content.- Impact of L-Carnitine Therapy on Lymphocyte Apoptosis, CD4 Cell Decline and HIV Viremia.- Concluding Remarks.- 12. Effect of L-Carnitine on the AZT-Induced Mitochondrial Toxicity: Studies on Human Muscle Cultures.- In Vitro Studies.- In Vivo Studies.- Conclusions.- 13. Possible Anti-Apoptotic Activity of Carnitines on Excitatory Amino Acid-Induced Neurotoxicity.- Glutamate and Cancer.- Glutamate May Mediate Some Neurological Disorders.- Pharmacotherapy for Excitatory Amino Acid-Induced Neurotoxicity.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 288 pp. Englisch.…

Codice articolo 9781461377511

Titolo
Carnitine Today
Autore
Giuseppe Famularo
Editore
Springer, Humana Mai 2014
Anno di pubblicazione
2014
Condizione
Neu
Rilegatura
Taschenbuch
Lingua
inglese
ISBN 10
146137751X
ISBN 13
9781461377511
Peso dell'articolo
441 grammi
Dimensioni
235x155x16 mm

buchversandmimpf2000

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ArticoloDa 60 a 60 giorni lavorativiDa 60 a 60 giorni lavorativi
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