Cefixime Trihydrate Sustained Release Matrix Tablet : To study the effect of different viscosity grade of HPMC on Cefixime Trihydrate sustained Release Matrix Tablet

Lingua: inglese

Editore: Scholars' Press, 2013

3639515536 / 9783639515534

Da: Buchpark, Trebbin, GermaniaBuchpark

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Venditore AbeBooks dal 30 settembre 2021

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Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | The present work aims to study effect of diff. viscosity grade of HPMC on cefixime trihydrate sustained release matrix tablet with a view to prolong drug release in vivo & reduce frequency of dosing. Cefixime Trihydrate is an orally active third generation cephalosporin and active against Gram+ve as well as Gram -ve bacteria. It has plasma half-life of 3-4 hrs. The Sustained release matrix tablets were prepared by wet granulation method using diff. grade of HPMC, Lactose, MCC & PVP K-30. The granules were subjected to pre-compression & post-compression parameters and they were in the acceptable limits. The in vitro drug release from HPMC matrices in accordance with its diff. proportion and viscosity grade was HPMC K-100M > K-15M > K-4M with ratio of (1, 1.5, 2) individually in formulation F1-F9 and (0.5, 0.75, 1) ratio in F10-F12. Drug-excipient interaction was performed by DSC & FTIR; results were shown that there was no interaction. After 3 months stability study at 400C/75% RH, formulations found to be stable. So as the viscosity and proportion of HPMC increases release rate from sustained release cefixime trihydrate matrix tablet decreases.…

Codice articolo 24260589/2

Titolo
Cefixime Trihydrate Sustained Release Matrix Tablet : To study the effect of different viscosity grade of HPMC on Cefixime Trihydrate sustained Release Matrix Tablet
Autore
Patel, Parth
Editore
Scholars' Press
Anno di pubblicazione
2013
Condizione
Sehr gut
Rilegatura
Brossura
Lingua
inglese
ISBN 10
3639515536
ISBN 13
9783639515534
Cataloghi dei venditori
Bücher

Buchpark

Trebbin, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 30 settembre 2021

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 60 a 60 giorni lavorativiDa 60 a 60 giorni lavorativi
Primo articoloEUR 105,00EUR 130,00
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