Cell Cycle Checkpoint Control Protocols

Lingua: inglese

Editore: Humana Nov 2010, 2010

1617373699 / 9781617373695

Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germaniabuchversandmimpf2000

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Venditore AbeBooks dal 23 gennaio 2017

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Descrizione dell’articolo da parte del venditore

This item is printed on demand - Print on Demand Titel. Neuware -The field of cell cycle regulation is based on the observation that the life cycle of a cell progresses through several distinct phases, G1, M, S, and G2, occurring in a well-defined temporal order. Details of the mechanisms involved are rapidly emerging and appear extraordinarily complex. Furthermore, not only is the order of the phases important, but in normal eukaryotic cells one phase will not begin unless the prior phase is completed successfully. Che- point control mechanisms are essentially surveillance systems that monitor the events in each phase, and assure that the cell does not progress prematurely to the next phase. If conditions are such that the cell is not ready to progress¿for example, because of incomplete DNA replication in S or DNA damage that may interfere with chromosome segregation in M¿a transient delay in cell cycle progression will occur. Once the inducing event is properly handled¿ for example, DNA replication is no longer blocked or damaged DNA is repaired¿cell cycle progression continues. Checkpoint controls have recently been the focus of intense study by investigators interested in mechanisms that regulate the cell cycle. Furthermore, the relationship between checkpoint c- trol and carcinogenesis has additionally enhanced interest in these cell cycle regulatory pathways. It is clear that cancer cells often lack these checkpoints and exhibit genomic instability as a result. Moreover, several tumor suppressor genes participate in checkpoint control, and alterations in these genes are as- ciated with genomic instability as well as the development of cancer.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch. …

Codice articolo 9781617373695

Titolo
Cell Cycle Checkpoint Control Protocols
Autore
Howard B. Lieberman
Editore
Humana Nov 2010
Anno di pubblicazione
2010
Condizione
Neu
Rilegatura
Taschenbuch
Lingua
inglese
ISBN 10
1617373699
ISBN 13
9781617373695
Peso dell'articolo
664 grammi
Dimensioni
235x155x25 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germania

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