Cloning, Expression And Purification Of Kir6.1 In Bacterial System

Waza, Ajaz Ahmad; Hussain, Mahboob Ul; Waza, Ajaz Ahmad; Hussain, Mahboob Ul

ISBN 10: 3659457027 / ISBN 13: 9783659457029

Editore: Lap Lambert Academic Publishing, 2013

92 pages. 8.66x5.91x0.21 inches. In Stock. Codice articolo 3659457027

Riassunto:

Adenosine-triphosphate-sensitive K+channels [K+(ATP)] are the protein channels responsive to changes in ATP/adenosine diphosphate (ADP) ratio and provide a means to couple movement of potassium ions, to relate membrane potential with cellular energy status. Various subfamilies of K+(ATP) channel proteins, designated as Kir1.0 to 7.0, share significant amino-acid homology (40%) among them. The Kir6.0 subfamily consists of Kir6.1 and Kir6.2 proteins with around 70% amino acid homology. Kir6.1 is widely expressed in tissues, including pancreatic islets, heart, skeletal muscle and brain. K+(ATP) channels are assembled from two different subunits, a Kir subunit that forms the ion-conducting pore and a sulfonylurea receptor (SUR), a member of the ABCC subfamily. Activation of an K+(ATP) channel is known to be an important part of endogenous protective signalling that promotes cellular survival under conditions of metabolic stress. More recently, evidences suggest that activation of sarcolemmal and mitochondrial K+(ATP) channels may promote cellular survival and act as central effector molecules in ischemic/hypoxia preconditioning.

L'autore: Ajaz Ahmad Waza (M.Sc, M.Phil); PhD SCHOLAR, DEPARTMENT OF BIOTECHNOLOGY, UNIVERSITY OF KASHMIR (190006).

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Titolo: Cloning, Expression And Purification Of ...
Casa editrice: Lap Lambert Academic Publishing
Data di pubblicazione: 2013
Legatura: Paperback
Condizione: Brand New