Colon Targeted Novel Drug Delivery Systems: Rheumatoid Arthritis
Uma Devi, S.K./ Narayanan, N./ Jaya Raja Kumar, K.
ISBN 10: 3659403644 ISBN 13: 9783659403644
Editore: LAP LAMBERT Academic Publishing, 2016
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Descrizione:
276 pages. 8.66x5.91x0.63 inches. In Stock. Codice articolo 3659403644
Riassunto:
The objective of the present study was directed towards developing a colon specific drug delivery system of aceclofenac, the non-steroidal anti-inflammatory drug associated with circadian rhythm of chronobiological symptoms for effective management of rheumatoid arthritis. Aceclofenac is a cox 2 selective inhibitor and has better safety than conventionalnon-steroidal anti-inflammatory drugs with respect to adverse effects on gastrointestinal and cardiovascular system. Aceclofenac is rapidly and completely absorbed after oral administration. Peak plasma concentration reaches in 1-3 h after an oral dose. The plasma elimination half life of the drug is approximately 4 h. The chronopharmacological approach for the management of rheumatoid arthritis has been well documented. Considering this factor, aceclofenac under investigation in the present study was developed as a colon targeted delivery system through tablets, pellets and microspheres. Additionally a Pulsincap drug delivery of the drug was also studied to meet the objective of circadian rhythm in rheumatoid arthritis.
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Titolo: Colon Targeted Novel Drug Delivery Systems: ...
Casa editrice: LAP LAMBERT Academic Publishing
Data di pubblicazione: 2016
Legatura: Paperback
Condizione: Brand New