This text covers catalytic methods for the preparation chiral compounds, required for pharmaceuticals, agricultural chemicals, and flavours and fragrances. The text provides an overview of the asymmetric catalysis field. It contains coverage on the basic principles, mechanisms and basis for stereoinduction, scope and limitations, and strategies and perspectives for future development.
Supplement 1:
6.1. T. Ohkuma, R. Noyori: Hydrogenation of Carbonyl Groups
6.2. T. Ohkuma, R. Noyori: Hydrogenation of Imino Groups
6.3. T. Ohkuma, R. Noyori: Hydrosilylation of Carbonyl and Imino Groups
14. T. Ohkuma, R. Noyori: Heck Reaction
26.1. K. Soai, T. Shibata: Alkylation of C=O
26.2. K. Hatanaka, H. Yamamoto: Alkylation of C=N
28. P. Vachal, E.N. Jacobsen: Cyanation of Carbonyl and Imino Groups
29.3. M. Shibasaki, H. Gröger, M. Kanai: Nitroaldol Reaction
31.2. M. Yamaguchi: Catalytic Conjugate Addition of Stabilized Carbanion
34.1. D.L. Hughes: Alkylation of Enolates
39. A.H. Hoveyda, K.E. Murphy: Combinatorial Approaches
New Chapters
16.4. H.M.L. Davies: C-H Insertion Reactions, Cycloadditions and Ylide Formation of Diazo Compounds
29.4. M. Shibasaki, N. Yoshikawa, S. Matsunaga: Direct Catalytic Asymmetric Aldol Reaction
29.5. S. Kobayashi, M. Ueno: Mannich Reaction
43. E.R. Jarvo, S.J. Miller: Acylation Reactions
44. A.H. Hoveyda, R.R. Schrock: Metathesis Reactions
Volume I
1 Introduction
Andreas Pfaltz
2 Historical Perspective
Henri B. Kagan
3 Basic Principles of Asymmetric Synthesis
Johann Mulzer
4 General Aspects of Asymmetric Catalysis
4.1 Non-Linear Effects and Autocatalysis
Henri B. Kagan, T. O. Luukas
5 Hydrogenation of Carbon-Carbon Double Bonds
5.1 Hydrogenation of Functionalized Carbon-Carbon Double Bonds
John M. Brown
5.2 Hydrogenation of Non-Functionalized Carbon-Carbon Double Bonds
Ronald L. Halterman
6 Reduction of Carbonyl and Imino Groups
6.1 Hydrogenation of Carbonyl Groups
T. Ohkuma á R. Noyori
6.2 Hydrogenation of Imino Groups
Hans-Ulrich Blaser, Felix Spindler
6.3 Hydrosilylation of Carbonyl and Imino Groups
Hisao Nishiyama
6.4 Hydroboration of Carbonyl Groups
Shinichi Itsuno
7 Hydrosilylation of Carbon-Carbon Double Bond
Tamio Hayashi
8 Hydroalumination of Carbon-Carbon Double Bonds
Mark Lautens, Tomislav Rovis
9 Hydroboration of Carbon-Carbon Double Bonds
Tamio Hayashi
10 Hydrocyanation of Carbon-Carbon Double Bonds
T.V. RajanBabu, Albert L. Casalnuovo
11 Hydrocarbonylation of Carbon-Carbon Double Bonds
Kyoko Nozaki
12 Hydrovinylation of Carbon-Carbon Double Bonds
T.V. RajanBabu
13 Carbometalation of Carbon-Carbon Double Bonds
Amir H. Hoveyda, Nicola M. Heron
14 Heck Reaction
Masakatsu Shibasaki, Erasmus M. Vogl
Volume II
15 Pauson-Khand Type Reactions
Stephen L. Buchwald, Frederick A. Hicks
16 Cyclopropanation and C-H Insertion Reactions
16.1 Cyclopropanation and C-H Insertion with Cu
Andreas Pfaltz
16.2 Cyc
