Computational Methods for Protein Structure Prediction and Modeling : Volume 1: Basic Characterization

Ying Xu

ISBN 10: 0387333193 / ISBN 13: 9780387333199

Editore: Springer New York, 2006

Riguardo questo articolo

Druck auf Anfrage Neuware - Printed after ordering - An ultimate goal of modern biology is to understand how the genetic blueprint of cells(genotype)determinesthestructure,function,andbehaviorofalivingorganism (phenotype). At the center of this scienti c endeavor is characterizing the bioch- ical and cellular roles of proteins, the working molecules of the machinery of life. A key to understanding of functional proteins is the knowledge of their folded str- tures in a cell, as the structures provide the basis for studying proteins' functions and functional mechanisms at the molecular level. Researchers working on structure determination have traditionally selected - dividual proteins due to their functional importance in a biological process or pa- way of particular interest. Major research organizations often have their own protein X-ray crystallographic or/and nuclear magnetic resonance facilities for structure - termination, which have been conducted at a rate of a few to dozens of structures a year. Realizing the widening gap between the rates of protein identi cation (through DNA sequencing and identi cation of potential genes through bioinformatics an- ysis) and the determination of protein structures, a number of large scienti c init- tives have been launched in the past few years by government funding agencies in the United States, Europe, and Japan, with the intention to solve protein structures en masse, an effort called structural genomics. A number of structural genomics centers (factory-like facilities) have been established that promise to produce solved protein structures in a similar fashion to DNA sequencing.

Codice articolo 9780387333199

Dati bibliografici

• Titolo: Computational Methods for Protein Structure Prediction and Modeling : Volume 1: Basic Characterization
• Editore: Springer New York
• Data di pubblicazione: 2006
• Lingua: Inglese
• ISBN 10: 0387333193
• ISBN 13: 9780387333199
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 240 L x 164 A x 24 P (millimetri) 240 millimetri di larghezza per 164 millimetri di altezza per 24 millimetri di profondità
• Peso: 703 grammi

Descrizione articolo

Riassunto

Focuses on the basic characterization of known protein structures, and structure prediction from protein sequence information. This title covers topics in modeling, force fields, classification, computational methods, and structure prediction.

Informazioni sull?autore

Dr. Ying Xu is Regents-GRA Eminent Scholar and Professor at the University of Georgia.  Dr. Dong Xu is the Director of the Digital Biology Laboratory at the University of Missouri-Columbia.  Dr. Jie Liang is the Director for the Center for Bioinformatics at the University of Illinois at Chicago.