Computational Pharmacokinetics

Kallen, Anders

ISBN 10: 1420060651 / ISBN 13: 9781420060652

Editore: Chapman and Hall/CRC, 2007

Riguardo questo articolo

Codice articolo 5189169-n

Dati bibliografici

Titolo: Computational Pharmacokinetics

Casa editrice: Chapman and Hall/CRC

Data di pubblicazione: 2007

Legatura: Rilegato

Condizione: New

Descrizione articolo

Riassunto:

Being that pharmacokinetics (PK) is the study of how the body handles various substances, it is not surprising that PK plays an important role in the early development of new drugs. However, the clinical research community widely believes that mathematics in some way blurs the true meaning of PK. Demonstrating that quite the opposite is true, Computational Pharmacokinetics outlines the fundamental concepts and models of PK from a mathematical perspective based on clinically relevant parameters. After an introductory chapter, the book presents a noncompartmental approach to PK and discusses the numerical analysis of PK data, including a description of an absorption process through numerical deconvolution. The author then builds a simple physiological model to better understand PK volumes and compares this model to other methods. The book also introduces compartmental models, discusses their limitations, and creates a general-purpose type of model. The final chapter looks at the relationship between drug concentration and effect, known as PK/pharmacodynamics (PD) modeling. With both a solid discussion of theory and the use of practical examples, this book will enable readers to thoroughly grasp the computational factors of PK modeling.

Informazioni sull?autore:

Kallen, Anders