Computer Simulation in Cell Radiobiology

Andrej Yu. Yakovlev

ISBN 10: 3540194576 / ISBN 13: 9783540194576

Editore: Springer Berlin Heidelberg, J.B. Metzler Jun 1988, 1988

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This item is printed on demand - it takes 3-4 days longer - Neuware -The search for ways to overcome tumour radioresistance is a major problem of experimental and clinical radiation oncology. The diffi culties involved in the attempts to solve this problem are a matter of common knowledge. In many a laboratory extensive studies are un derway of factors determining tumour tissue response to irradiation and of methods for exerting directional effect upon those factors. Such studies have revealed that, at least at the cellular level, a considerable number of factors manifest themselves which are respon sible for radiation effect (1] Among those are: spatial heteroge neity of tumour cell population producing radioresistant cell reser ves (hypoxic cells of solid tumours); differing radiosensitivities of cell life cycle phases; intrinsic dynamics of the processes of radi ation damage and postradiation cell recovery; induction of prolifera tive processes in response to the death of some cells within the po pulation; the stochastic nature of cell kinetics and complicated in teraction between individual cell subpopulations corresponding to di fferent tumour loci. Questions arise as to whether the researchers are now in possession of adequate means for interpreting experimental findings and clinical evidence and whether there are procedures for performing complex analysis and predicting specific tumour responses to various irradiation regimens and to combined antitumoral effects, taking into account the complexities of the phenomena under study. 140 pp. Englisch.

Codice articolo 9783540194576

Dati bibliografici

• Titolo: Computer Simulation in Cell Radiobiology
• Editore: Springer Berlin Heidelberg, J.B. Metzler Jun 1988
• Data di pubblicazione: 1988
• Lingua: Inglese
• ISBN 10: 3540194576
• ISBN 13: 9783540194576
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 229 L x 152 A x 8 P (millimetri) 229 millimetri di larghezza per 152 millimetri di altezza per 8 millimetri di profondità
• Peso: 215 grammi

Descrizione articolo

Riassunto

The search for ways to overcome tumour radioresistance is a major problem of experimental and clinical radiation oncology. The diffi­ culties involved in the attempts to solve this problem are a matter of common knowledge. In many a laboratory extensive studies are un­ derway of factors determining tumour tissue response to irradiation and of methods for exerting directional effect upon those factors. Such studies have revealed that, at least at the cellular level, a considerable number of factors manifest themselves which are respon­ sible for radiation effect (1] Among those are: spatial heteroge­ neity of tumour cell population producing radioresistant cell reser­ ves (hypoxic cells of solid tumours); differing radiosensitivities of cell life cycle phases; intrinsic dynamics of the processes of radi­ ation damage and postradiation cell recovery; induction of prolifera­ tive processes in response to the death of some cells within the po­ pulation; the stochastic nature of cell kinetics and complicated in­ teraction between individual cell subpopulations corresponding to di­ fferent tumour loci. Questions arise as to whether the researchers are now in possession of adequate means for interpreting experimental findings and clinical evidence and whether there are procedures for performing complex analysis and predicting specific tumour responses to various irradiation regimens and to combined antitumoral effects, taking into account the complexities of the phenomena under study.

Contenuti

Simulation in Cell Populations Kinetics.- A Simulation Model for In Vitro Kinetics of Normal and Irradiated Cells.- Simulation and Analysis Op Radiobiological Effects in Cell Cultures.- Simulation of Controlled Cell Systems.- The Properties of Cell Kinetics Indicators.- Conclusion.