Connexin Hemichannels : Methods and Protocols

Fabio Mammano

ISBN 10: 1071638416 / ISBN 13: 9781071638415

Editore: Springer, 2024

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Druck auf Anfrage Neuware - Printed after ordering - This volume explores the latest developments in the study of connexin hemichannels (HCs). The chapters in this book cover topics such as purification, reconstitution, and functional analysis of connexin HCs; spatial and temporal localization of connexins in cells using confocal microscopy; evaluation of connexin HC activity in vivo; generation of connexin-expressing stable cell pools; and automated assessment of cutaneous pathology in a mouse model of HC dysfunction. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Connexin Hemichannels: Methods and Protocols is a valuable resource that discusses the importance of HCs as drug targets, and how studying them is essential to identifying newcompounds capable of modulating HC function selectively and specifically.

Codice articolo 9781071638415

Dati bibliografici

• Titolo: Connexin Hemichannels : Methods and Protocols
• Editore: Springer
• Data di pubblicazione: 2024
• Lingua: Inglese
• ISBN 10: 1071638416
• ISBN 13: 9781071638415
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 260 L x 183 A x 18 P (millimetri) 260 millimetri di larghezza per 183 millimetri di altezza per 18 millimetri di profondità
• Peso: 613 grammi

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Riassunto

This volume explores the latest developments in the study of connexin hemichannels (HCs). The chapters in this book cover topics such as purification, reconstitution, and functional analysis of connexin HCs; spatial and temporal localization of connexins in cells using confocal microscopy; evaluation of connexin HC activity in vivo; generation of connexin-expressing stable cell pools; and automated assessment of cutaneous pathology in a mouse model of HC dysfunction. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Connexin Hemichannels: Methods and Protocols is a valuable resource that discusses the importance of HCs as drug targets, and how studying them is essential to identifying new compounds capable of modulating HC function selectively and specifically.