The DNA Damage Response: Implications on Cancer Formation and Treatment

Lingua: inglese

Editore: Springer, Springer Nov 2009, 2009

904812560X / 9789048125609

Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germaniabuchversandmimpf2000

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This item is printed on demand - Print on Demand Titel. Neuware -The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the ¿DNA damage response¿. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 464 pp. Englisch.…

Codice articolo 9789048125609

Titolo
The DNA Damage Response: Implications on Cancer Formation and Treatment
Autore
Kum Kum Khanna
Editore
Springer, Springer Nov 2009
Anno di pubblicazione
2009
Condizione
Neu
Rilegatura
Buch
Lingua
inglese
ISBN 10
904812560X
ISBN 13
9789048125609
Peso dell'articolo
942 grammi
Dimensioni
241x160x33 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germania

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ArticoloDa 60 a 60 giorni lavorativiDa 60 a 60 giorni lavorativi
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