DNA Microarrays and Related Genomics Techniques: Design, Analysis, and Interpretation of Experiments

ISBN 10: 0824754611 / ISBN 13: 9780824754617

Editore: CRC Press, 2005

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May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less 1.52. Codice articolo G0824754611I4N00

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Titolo: DNA Microarrays and Related Genomics ...

Casa editrice: CRC Press

Data di pubblicazione: 2005

Legatura: Hardcover

Condizione: Very Good

Condizione sovraccoperta: No Jacket

Descrizione articolo

Riassunto:

Considered highly exotic tools as recently as the late 1990s, microarrays are now ubiquitous in biological research. Traditional statistical approaches to design and analysis were not developed to handle the high-dimensional, small sample problems posed by microarrays. In just a few short years the number of statistical papers providing approaches to analyzing microarray data has gone from almost none to hundreds if not thousands. This overwhelming deluge is quite daunting to either the applied investigator looking for methodologies or the methodologist trying to keep up with the field. DNA Microarrays and Related Genomics Techniques: Design, Analysis, and Interpretation of Experiments consolidates discussions of methodological advances into a single volume.

The book’s structure parallels the steps an investigator or an analyst takes when conducting and analyzing a microarray experiment from conception to interpretation. It begins with foundational issues such as ensuring the quality and integrity of the data and assessing the validity of the statistical models employed, then moves on to cover critical aspects of designing a microarray experiment.  The book includes discussions of power and sample size, where only very recently have developments allowed such calculations in a high dimensional context, followed by several chapters covering the analysis of microarray data. The amount of space devoted to this topic reflects both the variety of topics and the effort investigators have devoted to developing new methodologies. In closing, the book explores the intellectual frontier – interpretation of microarray data. It discusses new methods for facilitating and affecting formalization of the interpretation process and the movement to make large high dimensional datasets public for further analysis, and methods for doing so.

There is no question that this field will continue to advance rapidly and some of the specific methodologies discussed in this book wil

L'autore:

David B. Allison, Grier P. Page, T. Mark Beasley, Jode W. Edwards