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Pages can have notes/highlighting. Spine may show signs of wear. ~ ThriftBooks: Read More, Spend Less 1.3. Codice articolo G0387203303I3N00
During the past three decades, clinical trials have evolved to become major research methodology for clinical medicine. Many statistical principles have been applied to the design, conduct, and anlysis of clinical trials, and these statistical methodologies continue to evolve as we apply clinical trials to an increasing array of research settings.
Dalla quarta di copertina:
Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obtaining the best evidence through clinical trials must be done within the boundaries of rigorous science and ethical principles. One fundamental principle is that trials should not continue longer than necessary to reach their objectives. Therefore, trials must be monitored for recruitment progress, quality of data, adherence to patient care or prevention standards, and early evidence of benefit or harm. Frequently, a group of external experts, independent from the investigators and trial sponsor, is charged with this monitoring responsibility, especially for safety and early benefit. This group is referred to by various names, such as a data monitoring committee or a data and safety monitoring board. This book, through a series of case studies presented by many distinguished clinical trial experts, illustrates the complexity of this monitoring process. The editors provide an overview of the process and a summary of a multitude of the lessons learned from the cases presented.
This book should be useful to anyone serving on a data and safety monitoring board, or planning to do so, for colleagues in academia, industry and governmental agencies, and for teaching students in biostatistics, epidemiology, clinical trials and medical ethics. No other text has as extensive a collection of cases which provide insight into the many issues, often conflicting, that must be examined before recommendations to continue or discontinue a trial can be made. While depth in statistical methods is not required, some familiarity with statistical design and analysis issues in clinical trials is helpful. The cases cover trials which were terminated early for convincing evidence of benefit, or for harmful effects. Cases with complex issues are also included. This series of cases should provide broad background information for potential monitoring committee members and better prepare them for the challenges that may exist in the trials for which they are responsible.
The three editors have contributed two overview chapters as well as several case studies to go along with cases contributed by a distinguished group of colleagues experienced in the design, monitoring and analysis of clinical trials. Dr. David DeMets is currently Professor and Chair, Department of Biostatistics and Medical Informatics at the University of Wisconsin-Madison. He is past president of the Eastern North American Region (ENAR) of the International Biometric Society, a past member of the Board of Directors of the American Statistical Association and an elected Fellow. He recently received the Robert Gordon Lectureship Award, given by the National Institutes of Health, for significant contributions to the field of clinical trials. Dr. Curt Furberg, is currently Professor (and former Chair) of the Department of Public Health Sciences at Wake Forest University. Previously, he was Head of the Clinical Trials Branch and Associate Director of the Clinical Applications and Prevention Program at the National Heart, Lung, and Blood Institute. Dr. Lawrence Friedman is a former Director of the Division of Epidemiology and Clinical Applications and a former Assistant Director for Ethics and Clinical Research at the National Heart, Lung, and Blood Institute. All three are past presidents of the Society of Clinical Trials. The editors have collaborated previously as coauthors of a text: the Fundamentals of Clinical Trials.
Titolo: Data Monitoring in Clinical Trials: A Case ...
Casa editrice: Springer
Data di pubblicazione: 2005
Legatura: Paperback
Condizione: Good
Condizione sovraccoperta: No Jacket
Da: HPB-Red, Dallas, TX, U.S.A.
paperback. Condizione: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority! Codice articolo S_416358988
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Da: BooksRun, Philadelphia, PA, U.S.A.
Paperback. Condizione: Good. 2006. Ship within 24hrs. Satisfaction 100% guaranteed. APO/FPO addresses supported. Codice articolo 0387203303-11-1
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Da: Anybook.com, Lincoln, Regno Unito
Condizione: Poor. This is an ex-library book and may have the usual library/used-book markings inside.This book has soft covers. In poor condition, suitable as a reading copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,700grams, ISBN:9780387203300. Codice articolo 9221217
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Da: Better World Books, Mishawaka, IN, U.S.A.
Condizione: Very Good. Used book that is in excellent condition. May show signs of wear or have minor defects. Codice articolo 38771125-75
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Da: Better World Books, Mishawaka, IN, U.S.A.
Condizione: Good. Used book that is in clean, average condition without any missing pages. Codice articolo 51845958-6
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Da: Lake Country Books and More, Excelsior, MN, U.S.A.
paperback. Condizione: Very Good +. Condizione sovraccoperta: None as issued. Name penned on first blank page, and that page also has a wrinkled corner. Rest of text is in excellent condition - crisp, clean and unmarked. Cover is glossy with mild surface and edge wear; light bend across back bottom edge. Binding is tight and square; no creases to spine. Light sun fading on and around spine. We are unable to ship oversize books and multi-volume sets internationally. Codice articolo FC22302160046
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Da: thebookforest.com, San Rafael, CA, U.S.A.
paperback. Condizione: New. Well packaged and promptly shipped from California. Partnered with Friends of the Library since 2010. Codice articolo 1LAUHV0027A5
Quantità: 1 disponibili
Da: moluna, Greven, Germania
Kartoniert / Broschiert. Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. From the authors of Fundamentals of Clinical Trials which has sold over 15,000 copies world wide since its publication in 1998.No competition yet as the text does not focus on how to do clinical trials but on very specific situations that can be. Codice articolo 5909048
Quantità: Più di 20 disponibili
Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania
Taschenbuch. Condizione: Neu. Neuware -Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obtaining the best evidence through clinical trials must be done within the boundaries of rigorous science and ethical principles. One fundamental principle is that trials should not continue longer than necessary to reach their objectives. Therefore, trials must be monitored for recruitment progress, quality of data, adherence to patient care or prevention standards, and early evidence of benefit or harm. Frequently, a group of external experts, independent from the investigators and trial sponsor, is charged with this monitoring responsibility, especially for safety and early benefit. This group is referred to by various names, such as a data monitoring committee or a data and safety monitoring board. This book, through a series of case studies presented by many distinguished clinical trial experts, illustrates the complexity of this monitoring process. The editors provide an overview of the process and a summary of a multitude of the lessons learned from the cases presented.This book should be useful to anyone serving on a data and safety monitoring board, or planning to do so, for colleagues in academia, industry and governmental agencies, and for teaching students in biostatistics, epidemiology, clinical trials and medical ethics. No other text has as extensive a collection of cases which provide insight into the many issues, often conflicting, that must be examined before recommendations to continue or discontinue a trial can be made. While depth in statistical methods is not required, some familiarity with statistical design and analysis issues in clinical trials is helpful. The cases cover trials which were terminated early for convincing evidence of benefit, or for harmful effects. Cases with complex issues are also included. This series of cases should provide broad background information for potentialmonitoring committee members and better prepare them for the challenges that may exist in the trials for which they are responsible.'This book is a must-read for individuals serving on or supporting data monitoring committees as well as statisticians and other disciplines involved in the design and analysis of clinical trials with interim monitoring.' Journal of Biopharmaceutical Sciences, Issue 6, 2006Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 404 pp. Englisch. Codice articolo 9780387203300
Quantità: 2 disponibili
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -From the authors of 'Fundamentals of Clinical Trials' which has sold over 15,000 copies world wide since its publication in 1998.No competition yet as the text does not focus on how to do clinical trials but on very specific situations that can be encountered during the process. 404 pp. Englisch. Codice articolo 9780387203300
Quantità: 2 disponibili