Design and Optimization in Organic Synthesis (Data Handling in Science and Technology, Band 8)

Carlson, Rolf

ISBN 10: 044489201X / ISBN 13: 9780444892010

Editore: Elsevier Science Ltd, 1992

Riguardo questo articolo

Zustand: Sehr gut | Seiten: 552 | Produktart: Sonstiges.

Codice articolo 42482292/202

Dati bibliografici

• Titolo: Design and Optimization in Organic Synthesis (Data Handling in Science and Technology, Band 8)
• Editore: Elsevier Science Ltd
• Data di pubblicazione: 1992
• Lingua: Inglese
• ISBN 10: 044489201X
• ISBN 13: 9780444892010
• Rilegatura: Rilegato
• Edizione: terza edizione
• Condizione: Sehr gut
• Cataloghi dei venditori:
  • Sonstiges

Descrizione articolo

Riassunto

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.