Design and Synthesis of 1,4-Diazepines as Selective Cox-II Inhibitors

Chirag J. Patel

ISBN 10: 3659337862 / ISBN 13: 9783659337864

Editore: LAP LAMBERT Academic Publishing Feb 2013, 2013

Riguardo questo articolo

Neuware -The NSAIDs have known to cause serious problems such as gastric ulceration, bleeding and renal disorders on long term medication. These severe side effects are partially due to their nonselectivity towards to COX-2 enzyme. Hence, newer, selective COX-2 enzyme inhibitors have been developed to overcome the toxicity problems. Recently, Rofecoxib and Celecoxib were withdrawn due to cardiac toxicity.1,2-disubstituted five-membered heterocyclic compounds have shown selectivity towards COX-2 inhibition. But, the toxicity reports of drugs like Rofecoxib and Celecoxib in this category prompted us to synthesize 1,2-diaryl diazepines (E) and their derivatives as, survey of literature indicated the diazepine heterocyclic system to have anti-inflammatory activity.Books on Demand GmbH, Überseering 33, 22297 Hamburg 68 pp. Englisch.

Codice articolo 9783659337864

Dati bibliografici

• Titolo: Design and Synthesis of 1,4-Diazepines as Selective Cox-II Inhibitors
• Editore: LAP LAMBERT Academic Publishing Feb 2013
• Data di pubblicazione: 2013
• Lingua: Inglese
• ISBN 10: 3659337862
• ISBN 13: 9783659337864
• Rilegatura: Taschenbuch
• Condizione: Neu

Descrizione articolo

Riassunto

The NSAIDs have known to cause serious problems such as gastric ulceration, bleeding and renal disorders on long term medication. These severe side effects are partially due to their nonselectivity towards to COX-2 enzyme. Hence, newer, selective COX-2 enzyme inhibitors have been developed to overcome the toxicity problems. Recently, Rofecoxib and Celecoxib were withdrawn due to cardiac toxicity.1,2-disubstituted five-membered heterocyclic compounds have shown selectivity towards COX-2 inhibition. But, the toxicity reports of drugs like Rofecoxib and Celecoxib in this category prompted us to synthesize 1,2-diaryl diazepines (E) and their derivatives as, survey of literature indicated the diazepine heterocyclic system to have anti-inflammatory activity.

L'autore

Prof. Chirag J. Patel, Ph.D. fellow in Pharmaceutical Sciences at K.S.K.V. Kachchh University, Bhuj-Kachchh, Gujarat, INDIA. Field of Study: Phytopharmacoligal Screening of Some Laticiferous Plants & Drug Design with Development. Presently working as an Associate Professor at Veerayatan Institute of Pharmacy, India from last seven years.