Detection of Methylated RAR in the Urine of Bladder Cancer Patients : Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine

Lingua: inglese

Editore: LAP LAMBERT Academic Publishing, 2012

3847379240 / 9783847379249

Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

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Descrizione dell’articolo da parte del venditore

nach der Bestellung gedruckt Neuware - Printed after ordering - Bladder cancer is an important public health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer patients, so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of RAR 2 tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated RAR 2 gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary RAR 2 promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of RAR 2 promoter hypermethylation was (83.6%) and the specificity was (89.7%), while the sensitivity of urine cytology was (52.2%). Combined use of detection of urinary RAR 2 promoter hypermethylation with urine cytology increased the sensitivity of cytology from 52.2% to 89.5%.…

Codice articolo 9783847379249

Titolo
Detection of Methylated RAR in the Urine of Bladder Cancer Patients : Molecular screening of bladder cancer Project PI: Sanaa Eissa Ain Shams Faculty of Medicine
Autore
Ahmed Ibrahim
Editore
LAP LAMBERT Academic Publishing
Anno di pubblicazione
2012
Condizione
Neu
Rilegatura
Taschenbuch
Lingua
inglese
ISBN 10
3847379240
ISBN 13
9783847379249
Peso dell'articolo
387 grammi
Dimensioni
220x150x16 mm

AHA-BUCH GmbH

Einbeck, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 7 a 10 giorni lavorativiDa 5 a 7 giorni lavorativi
Primo articoloEUR 35,00EUR 45,00
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