Development of a New Computational Approach to the Prediction of Nucleic Acid

Lingua: inglese

Editore: Forgotten Books, 2024

1333716362 / 9781333716363

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Da: Forgotten Books, London, Regno UnitoForgotten Books

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Print on Demand. This book presents the development of a novel computational approach to predict the three-dimensional structure of deoxyribose nucleic acids by potential energy methods. The significance of the approach lies in its ability to incorporate experimental data known from crystal structures of small molecules, and to make reliable predictions of structures of larger biological systems. The author's strategy consists of representing the molecular conformation in cartesian coordinate space with the full set of degrees of freedom associated with the molecular conformation, allowing all bond lengths and bond angles as well as dihedral angles to vary. All the interactions other than the non-bonded terms are represented by polynomials of the coordinate variables. This formulation allows direct differentiation with respect to the cartesian variables and facilitates manipulation and differentiation of the energy terms. The text examines in detail the influence of different potential energy sets on the structures obtained and on the C3' endo/C2' endo energy difference. The author explores the contribution of each energy potential from Energy versus P (the pseudorotation parameter) profiles. These curves also provide an opportunity to investigate the approximation made in the pseudorotation description. The concluding insights of this book are significant because they provide a deeper understanding of the correlation between conformation and biological function, offering a valuable tool for revealing details of molecular conformation, motion, and associated biological functions. This book is a reproduction of an important historical work, digitally reconstructed using state-of-the-art technology to preserve the original format. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in the book.…

Codice articolo 9781333716363_0

Titolo
Development of a New Computational Approach to the Prediction of Nucleic Acid
Autore
Tamar Schlick, Charles Peskin
Editore
Forgotten Books
Anno di pubblicazione
2024
Condizione
New
Tipo di libro
print-on-demand item
Rilegatura
Paperback
Lingua
inglese
ISBN 10
1333716362
ISBN 13
9781333716363
Cataloghi dei venditori
Calculus

Forgotten Books

London, Regno Unito

Venditore con 5 stelle

Venditore AbeBooks dal 2 giugno 2021

Tariffe di spedizione da Regno Unito a U.S.A.

ArticoloDa 5 a 10 giorni lavorativiDa 5 a 10 giorni lavorativi
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Forgotten Books’ Classic Reprint Series utilizes the latest technology to regenerate facsimiles of historically important writings. Careful attention has been made to accurately preserve the original format of each page whilst digitally enhancing the quality of the aged text.

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