Divalproex sodium floating microspheres - Design and Quantification

Subashini Rajaram (u. a.)

ISBN 10: 6139893119 / ISBN 13: 9786139893119

Editore: LAP LAMBERT Academic Publishing, 2018

Divalproex sodium floating microspheres - Design and Quantification | Subashini Rajaram (u. a.) | Taschenbuch | 124 S. | Englisch | 2018 | LAP LAMBERT Academic Publishing | EAN 9786139893119 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Codice articolo 114327418

Riassunto:

Any drug delivery system that enhances the therapeutic effectiveness of incorporated drugs by providing sustained, controlled delivery and or targeting the drug to desired site is always invitable. Among various route of administration oral route is the most compact, painless, safest and least expensive, it is the most often used. The present study aimed to develop a floating microsphere of Divalproex sodium for Epilepsy. The microspheres were prepared by emulsification crosslinking method using gluteraldehyde as crosslinking agent and chitosan as polymer. The microspheres were characterized for pre and post compression evaluations. In- vitro percentage drug release results shown that there was markedly extended release when chitosan concentration and molecular weight was increased. This may due to crosslinking of aldehyde groups of the glutaraldehyde form covalent amine bonds with the amino groups of chitosan and also due to the resonance established with adjacent double ethylenic bonds via Schiff reaction.Thus, this approach could be beneficial for the treatment of epilepsy with improved dissolution and absorption.

Dati bibliografici

Titolo: Divalproex sodium floating microspheres - ...
Casa editrice: LAP LAMBERT Academic Publishing
Data di pubblicazione: 2018
Legatura: Taschenbuch
Condizione: Neu