Drug Discovery and Development : Technology in Transition

Hill, R. G., Ph.D. (EDT); Rang, H. P. (EDT); Vallance, Patrick (FRW)

ISBN 10: 0702042994 / ISBN 13: 9780702042997

Editore: Churchill Livingstone, 2012

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Codice articolo 18239369-5

Dati bibliografici

• Titolo: Drug Discovery and Development : Technology in Transition
• Editore: Churchill Livingstone
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 0702042994
• ISBN 13: 9780702042997
• Rilegatura: Brossura
• Edizione: seconda edizione
• Condizione: good

Descrizione articolo

Riassunto

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries' trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market.

Contenuti

Contents

SECTION 1

INTRODUCTION AND BACKGROUND

1. The development of the pharmaceutical industry

H P Rang

2. The nature of disease and the purpose of therapy

H P Rang, R G Hill

3. Therapeutic modalities

H P Rang, H LeVine, R G Hill

SECTION 2

DRUG DISCOVERY

4. The drug discovery process: general principles and some case histories

H P Rang, R G Hill

5. Choosing the project

H P Rang, R G Hill

6. Choosing the target

H P Rang, R G Hill

7. The role of information, bioinformatics and genomics

B Robson, R McBurney

8. High-throughput screening

D Cronk

9. The role of medicinal chemistry in the drug discovery process

P Beswick, A Naylor

10. DMPK optimization strategy in drug discovery

P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn

11. Pharmacology: its role in drug discovery

H P Rang

12. Biopharmaceuticals

H LeVine

13. Scaffolds: Small globular proteins as antibody substitutes

D Grabulovski, J Bertschinger

SECTION 3

DRUG DEVELOPMENT

14. Drug development: introduction

H P Rang, R G Hill

15. Assessing drug safety

H P Rang, R G Hill

16. Pharmaceutical developmentT Lundqvist, S Bredenberg

17. Clinical Development - Present and Future

C Keywood

18. Clinical imaging in drug development

P M Matthews

19. Intellectual property in drug discovery and development

P Grubb

20. Regulatory affairs

I Hägglöf, Å Holmgren

21. Marketing the drug

V L Lawton

SECTION 4

FACTS AND FIGURES

22. Drug discovery and development - facts and figures

H P Rang, R G Hill