Drug Toxicity in Embryonic Development: Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk Vol. 1 (Handbook of Experimental Pharmacology)

R.J. Kavlock and G.P Daston

ISBN 10: 3540612599 / ISBN 13: 9783540612599

Editore: Springer, UK, 1996

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3540612599. Handbook of Experimental Pharmacology, Volume 124/I. Hardcover, from closed pharmaceutical company library, appears unread. 638 pages, index, illustrated with charts, tables, colour photos and diagrams. Prevention of birth defects caused by exogenous chemicals is a goal of both primary care providers, drug developers, experimental teratologists, and risk assessors. This two-volume work provides assessment of how embryos accomplish morphogenesis at the molecular and cellular level, the key biochemical processes that drive morphogenesis and which are thus at risk to disruption, and the mechanisms of action by which known teratogens exert their effects. These volumes provide the first comprehensive compilation of material focused on the understanding of the mechanism of action of chemicals which cause birth defects. A valuable reference work for clinicians, health councilors, teratologists, developmental biologists and risk assessors. Contents clean, tight and bright.

Codice articolo 20734

Dati bibliografici

• Titolo: Drug Toxicity in Embryonic Development: Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk Vol. 1 (Handbook of Experimental Pharmacology)
• Editore: Springer, UK
• Data di pubblicazione: 1996
• Lingua: Inglese
• ISBN 10: 3540612599
• ISBN 13: 9783540612599
• Rilegatura: Hardcover
• Condizione: Near Fine
• Tipo di libro: Book

Descrizione articolo

Riassunto

Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.