The Dynamic Neuron

Smythies M.D. F.R.C.P., John

ISBN 10: 0262194732 / ISBN 13: 9780262194730

Editore: Bradford Book, 2002

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Dati bibliografici

• Titolo: The Dynamic Neuron
• Editore: Bradford Book
• Data di pubblicazione: 2002
• Lingua: Inglese
• ISBN 10: 0262194732
• ISBN 13: 9780262194730
• Rilegatura: Rilegato
• Condizione: nuovo

Descrizione articolo

Riassunto

A comprehensive review of current research on synaptic plasticity.

The traditional model of synapses as fixed structures has been replaced by a dynamic one in which synapses are constantly being deleted and replaced. This book, written by a leading researcher on the neurochemistry of schizophrenia, integrates material from neuroscience and cell biology to provide a comprehensive account of our current knowledge of the neurochemical basis of synaptic plasticity.

The book presents the evidence for synaptic plasticity, an account of the dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the biochemical basis of the Hebbian synapse. It discusses the role of endocytosis, special proteins, and local protein synthesis. Additional topics include volume transmission, arachidonic acid signaling, hormonal modulation, and psychological stress. Finally, the book considers pharmacological and clinical implications of current research, particularly with reference to schizophrenia and Alzheimer's disease.

Informazioni sull?autore

John Smythies is Director of the Division of Neurochemistry, Center for Brain and Cognition, University of California, San Diego; Senior Research Fellow, Institute of Neurology, Queen Square, London; and Visiting Professor, Department of Psychiatry, Harvard Medical School.