Epithelial-Mesenchymal Interactions in Cancer

Eliot M. Rosen

ISBN 10: 3034898932 / ISBN 13: 9783034898935

Editore: Birkhäuser Basel, Springer Basel Sep 2011, 2011

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This item is printed on demand - Print on Demand Titel. Neuware -gar discusses recent studies of the SF gene promoter that may be relevant to understanding the detailed molecular mechanism(s) by which soluble factors regulate SF production. Polverini and Nickoloff discuss another mechanism by which SF may enhance tumor growth, ie., stimulation of angiogenesis, the formation of new blood vessels from pre-existing microvessels. Angiogenesis is required for continued growth of most solid tumors, and provides a mechanism by which the stroma may continue to grow along with the tumor cells. Although endothelial cells are stromal cells, they express a number of epithelial characteristics including (i) epithelial-like tight junctions and junctional proteins; (ii) the ability to organize into flat tened tubular structures; (iii) the c-met receptor protein; and (iv) biologic responsiveness to SF. It is, perhaps, not surprising that vascular endothe lial cells may both produce and respond to SF in different situations. 'Epithelialness' may be defined in two ways: (i) expression of generic epithelial structures and proteins (eg., specialized junctions, junctional proteins [eg., cadherins, ZOl], cytokeratins); and (ii) production of specific differentiated products (eg., milk proteins by mammary epithelia, renin by renal tubular epithelia of the juxtaglomerular apparatus). Recent studies suggest that SF Ic-met signalling may mediate epithelia mesenchyme interconversion, in part by modifying some of the generic epithelial characteristics. Nusrat discusses the effects of SF on the epithelial junctional apparatus. Relatively little is known about whether and how SF regulates cell-specific differentiation.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 316 pp. Englisch.

Codice articolo 9783034898935

Dati bibliografici

• Titolo: Epithelial-Mesenchymal Interactions in Cancer
• Editore: Birkhäuser Basel, Springer Basel Sep 2011
• Data di pubblicazione: 2011
• Lingua: Inglese
• ISBN 10: 3034898932
• ISBN 13: 9783034898935
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 244 L x 170 A x 18 P (millimetri) 244 millimetri di larghezza per 170 millimetri di altezza per 18 millimetri di profondità
• Peso: 548 grammi

Descrizione articolo

Riassunto

The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.

Contenuti

Epithelial-mesenchymal transitions in development and tumor progression.- Regulation of scatter factor (hepatocyte growth factor) production by tumor-stroma interaction.- Regulation of HGF and HGFR gene expression.- The role of scatter factor and the c-met proto-oncogene in angiogenic responses.- Modulation of intercellular junctions of epithelia by scatter factor (hepatocyte growth factor).- The Met-HGF/SF autocrine signaling mechanism is involved in sarcomagenesis.- Tumor cell interactions with the vascular endothelium and their role in cancer metastasis.- Stimulation and regulation of tumor cell motility in invasion and metastasis.- Tumor-stromal cytokine interactions in ovarian neoplasms.- Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction.- Stromal-epithelial interaction in type IV collagenase expression and activation: The role in cancer metastasis.- Angiogenesis as a component of epithelial-mesenchymal interactions.- Mammary tumor fibroblasts are phenotypically distinct from non-tumor fibroblasts.- Fibroblast subpopulations as accelerators of tumor progression: The role of migration stimulating factor.