Estimands, Estimators and Sensitivity Analysis in Clinical Trials

Lingua: inglese

Editore: Chapman And Hall/CRC Dez 2021, 2021

1032242620 / 9781032242620

Serie: Libro 106 di 155 - Chapman & Hall/CRC Biostatistics

Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

Venditore con 5 stelle

Venditore AbeBooks dal 11 gennaio 2012

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This item is printed on demand - it takes 3-4 days longer - Neuware -The concepts of estimands, analyses (estimators), and sensitivity are interrelated. Therefore, great need exists for an integrated approach to these topics. This book acts as a practical guide to developing and implementing statistical analysis plans by explaining fundamental concepts using accessible language, providing technical details, real-world examples, and SAS and R code to implement analyses. The updated ICH guideline raises new analytic and cross-functional challenges for statisticians. Gaps between different communities have come to surface, such as between causal inference and clinical trialists, as well as among clinicians, statisticians, and regulators when it comes to communicating decision-making objectives, assumptions, and interpretations of evidence.This book lays out a path toward bridging some of these gaps. It offers¿ A common language and unifying framework along with the technical details and practical guidance to help statisticians meet the challenges¿ A thorough treatment of intercurrent events (ICEs), i.e., postrandomization events that confound interpretation of outcomes and five strategies for ICEs in ICH E9 (R1)¿ Details on how estimands, integrated into a principled study development process, lay a foundation for coherent specification of trial design, conduct, and analysis needed to overcome the issues caused by ICEs:¿ A perspective on the role of the intention-to-treat principle¿ Examples and case studies from various areas¿ Example code in SAS and R¿ A connection with causal inference¿ Implications and methods for analysis of longitudinal trials with missing dataTogether, the authors have offered the readers their ample expertise in clinical trial design and analysis, from an industrial and academic perspective. 346 pp. Englisch.…

Codice articolo 9781032242620

Titolo
Estimands, Estimators and Sensitivity Analysis in Clinical Trials
Autore
Craig Mallinckrodt
Editore
Chapman And Hall/CRC Dez 2021
Anno di pubblicazione
2021
Condizione
Neu
Rilegatura
Taschenbuch
Lingua
inglese
ISBN 10
1032242620
ISBN 13
9781032242620
Peso dell'articolo
526 grammi
Dimensioni
234x156x19 mm
Serie
Libro 106 di 155: Chapman & Hall/CRC Biostatistics

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 11 gennaio 2012

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 5 a 15 giorni lavorativiDa 5 a 15 giorni lavorativi
Primo articoloEUR 23,00EUR 23,00
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