Many complex traits define the primate condition, including behaviors as fundamental as locomotion and traits as scrutinized as the dentition, and their study reveals dramatic evolutionary change across the primates. Genetic modifications are at the basis of these changes, but transformation of genetic information into phenotypes occurs at the level of the cell, which is the focus of this book. Contributors summarize novel methodologies to analyze the collective behavior of cells in forming tissues and organs influencing physiological functions and anatomical features that enable behaviors. Our goal is to review current knowledge and encourage others to adopt evolutionary cell biology to aid in deciphering the genotype-phenotype map that underlies the diversification of primates, human variation, and human evolution. The contributors to this book utilize advances in genetic analysis and visualization of cells and tissues and merge evolutionary developmental biology with evolutionary cell biology to address questions central to understanding human and primate evolution.

Key Features

Explores mechanisms underlying trait development, distribution, variation, and evolution, especially with respect to pigmentation, dental formulae, the skeleton, energetics, and temperature-related morphological variation

Documents the advantages for anthropologists to work at the level of cells, focusing on how genes provide instructions for cells to make structure and how environment affects the behavior of cells

Illustrates the role cell biology plays in pelage growth and pigmentation, facial morphology, melanin production in pigmentation, dental development and tooth loss, and energy expenditure

Describes novel methodologies and techniques to analyze environment- and temperature-related influences on phenotypes

Demonstrates how significant changes in life history occur at the level of the cell

Related Titles

Bianchi, L. Developmental Neurobiology (ISBN 978-0-8153-4482-7)

King, G. R. Primate Behavior and Human Origins (ISBN 978-1-138-85317-1)

Rhys Evans, P. H. The Waterside Ape: An Alternate Account of Human Evolution (ISBN 978-0-367-14548-4)

Informazioni sull'autore

M. Kathleen Pitirri, PhD is a Postdoctoral Scholar in the Department of Anthropology at Pennsylvania State University. She received her PhD from the University of Toronto in 2019 where she studied primate evolution, focusing specifically on the taxonomic, ontogenetic, and functional basis of mandibular shape variation in living and fossil primates. During her PhD research, Dr. Pitirri developed a novel methodology for studying shape variation of mandibular fragments that are part of the primate fossil record. She found a strong relationship between the shape of the mandibular corpus and molar crypt formation in great apes, suggesting that mandibular shape is linked to an extended period of development in great apes, representing an important evolutionary shift in primates. Upon joining the Richtsmeier Lab, Dr. Pitirri began using mouse models to study the cellular mechanisms involved in transferring information from the genotype to the phenotype. The changes observed in mouse models can be used to interpret the cellular basis for changes observed in skull shape in primates because mechanisms that build the craniofacial skeleton during development also drive variation in disease and evolution. Dr. Pitirri is particularly interested in the evolutionary consequences of change in developmental processes driving the patterning of cellular activities involved in embryogenesis of skull bones, the role of the chondrocranium in skull development, and the genetic pathways regulating the relationship between tooth and bone formation during embryonic development.

Joan Richtsmeier is Distinguished Professor of Anthropology at the Pennsylvania State University. She received her PhD from Northwestern University in 1985 and joined the faculty of the Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine in 1986. There, she focused on establishing new quantitative methods for studying change in biological shape through time, especially in primates, with Professor Subhash Lele. In 1999 she became the 55th woman to achieve the rank of Professor at Johns Hopkins University School of Medicine since the school opened in 1893. In 2000, Dr. Richtsmeier moved her lab to the Pennsylvania State University. There, her focus turned to joining developmental biology with evolutionary biology, and with collaborators and students, she has worked to integrate the study of mouse models carrying known genetic variants with understanding the biological basis of patterns of evolutionary change. She is particularly interested in early formation of the chondrocranium and how and why cells decide to become osteoblasts and make bone. Dr. Richtsmeier was elected Fellow of the American Association of Anatomists (AAA) in 2018, received the Henry Gray Scientific Achievement Award of the AAA in 2019, and the David Bixler Excellence in Craniofacial Research Award of the Society for Craniofacial Genetics and Developmental Biology in 2019. She was elected Fellow of the AAAS (Section on Biological Sciences) in 2020. Her work is supported by grants from the National Science Foundation, the National Institutes of Health, and the Wellcome Trust.

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