Extracellular Matrix Degradation

Parks, William C. (Editor)/ Mecham, Robert P. (Editor)

ISBN 10: 3642168604 / ISBN 13: 9783642168604

Editore: Springer Verlag, 2011

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265 pages. 9.00x6.00x0.75 inches. In Stock.

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Dati bibliografici

• Titolo: Extracellular Matrix Degradation
• Editore: Springer Verlag
• Data di pubblicazione: 2011
• Lingua: Inglese
• ISBN 10: 3642168604
• ISBN 13: 9783642168604
• Rilegatura: Hardcover
• Condizione: Brand New
• Peso: 0,55 chilogrammi

Descrizione articolo

Riassunto

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Dalla quarta di copertina

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.