Formulation and Evaluation of Fast Dissolving Tablet of Clopidogrel | Fast Dissolving Tablets

Vinay Pandit (u. a.)

ISBN 10: 6200535078 / ISBN 13: 9786200535078

Editore: LAP LAMBERT Academic Publishing, 2020

Formulation and Evaluation of Fast Dissolving Tablet of Clopidogrel | Fast Dissolving Tablets | Vinay Pandit (u. a.) | Taschenbuch | 108 S. | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786200535078 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Codice articolo 118001130

Riassunto:

The present investigation involves formulation and evaluation of fast dissolving tablet of clopidogrel, which is used to prevent coronary disorder. Platelet aggregation is part of the sequence events leading to the formulation of a thrombus (clot). Antiplatelet therapy with one or more drugs decreases the ability of blood clot to form by interfering with the platelet activation process in primary homeostasis. Tablets were formulated by three different methods Viz., Direct compression method, Solid dispersion method and Sublimation method. Different excipients such as, crospovidone as super disintegrants, croscarmellose as superdisintegrant, magnesium stearate as lubricant, talc as glidant etc. were used. Based on in-vitro release studies tablets prepared by sublimation method clopidogrel was selected as optimizes formulation. In-vitro release studies indicated more than 95% release of drug in 30 mins. The accurate stability studies indicated no change in in-vitro release and other property of the tablet. Thus sublimation method can be a promising strategy in enhancing the solubility and dissolution studies of clopidogrel bisulphate.

Dati bibliografici

Titolo: Formulation and Evaluation of Fast ...
Casa editrice: LAP LAMBERT Academic Publishing
Data di pubblicazione: 2020
Legatura: Taschenbuch
Condizione: Neu