Genetic Epidemiology : Methods and Applications

Austin, Melissa A.; Beaty, Terri H.; Dotson, W. David; Edwards, Kelly; Fullerton, Stephanie M.

ISBN 10: 1780641818 / ISBN 13: 9781780641812

Editore: CAB International, 2013

Unread book in perfect condition. Codice articolo 19510970

Riassunto:

Genetic epidemiology plays a key role in discovering genetic factors influencing health and disease, and in understanding how genes and environmental risk factors interact. There is growing interest in this field within public health, with the goal of translating the results into promoting health and preventing disease in both families and populations.

This textbook provides graduate students with a working knowledge of genetic epidemiology research methods. Following an overview of the field, the book reviews key genetic concepts, provides an update on relevant genomic technology, including genome-wide chips and DNA sequencing, and describes methods for assessing the magnitude of genetic influences on diseases and risk factors. The book focuses on research study designs for discovering disease susceptibility genes, including family-based linkage analysis, candidate gene and genome-side association studies, assessing gene-environment interactions and epistasis, studies of Non-Mendelian inheritance, and statistical analyses of data from these studies. Specific applications of each research method are illustrated using a variety of diseases and risk factors relevant to public health, and useful web-based genetic analysis software, human reference panels, and repositories, that can greatly facilitate this work, are described.

Concluding with a review of ethical issues and a framework for translating human genomics research to clinical practice and public health benefit, this textbook is an essential new resource for graduate students in epidemiology and public health genetics.

Product Description: Genetic Epidemiology:Methods And Application, Modular Text Series by Austin M, 9781780641812, Cabi, 2013, Paperback

Dati bibliografici

Titolo: Genetic Epidemiology : Methods and ...
Casa editrice: CAB International
Data di pubblicazione: 2013
Legatura: Brossura
Condizione: As New