The Genetics of Coeliac Disease

R. B. McConnell

ISBN 10: 9401181160 / ISBN 13: 9789401181167

Editore: Springer Nature B.V. Mai 2012, 2012

Neuware - R. B. McConnell During the past 10 years three international symposia on coeliac disease have been held. The first was in London in 1969, the second in Leiden in 1973 and the third in Galway in 1977. At each there were contributions on the familial, hereditary or genetic aspects of the disease but because all features of the condition were being considered at the symposia there was not the time for detailed discussion of the genetic aspects. These three international symposia were sponsored by Mr Jeremiah Milner and Welfare Foods (Stockport) Limited. During 1978 Mr Milner and I were aware of intensive studies being at various centres in Europe and America on the genetics of made coeliac disease, and we decided that to bring these teams together and let the members spend a whole day discussing the genetics of coeliac disease might well result in a valuable exchange of data and ideas; the discussions could also point to the most potentially fruitful avenues for further research. Professor Charlotte Anderson, Dr C. C. Booth and Professor Ciaron McCarthy joined Mr, Milner and me in forming a Steering Committee, and the International Symposium on the Genetics of Coeliac Disease was held in the Liverpool Medical Institution on 28 and 29 November 1979. Codice articolo 9789401181167

Riassunto:

R. B. McConnell During the past 10 years three international symposia on coeliac disease have been held. The first was in London in 1969, the second in Leiden in 1973 and the third in Galway in 1977. At each there were contributions on the familial, hereditary or genetic aspects of the disease but because all features of the condition were being considered at the symposia there was not the time for detailed discussion of the genetic aspects. These three international symposia were sponsored by Mr Jeremiah Milner and Welfare Foods (Stockport) Limited. During 1978 Mr Milner and I were aware of intensive studies being at various centres in Europe and America on the genetics of made coeliac disease, and we decided that to bring these teams together and let the members spend a whole day discussing the genetics of coeliac disease might well result in a valuable exchange of data and ideas; the discussions could also point to the most potentially fruitful avenues for further research. Professor Charlotte Anderson, Dr C. C. Booth and Professor Ciaron McCarthy joined Mr, Milner and me in forming a Steering Committee, and the International Symposium on the Genetics of Coeliac Disease was held in the Liverpool Medical Institution on 28 and 29 November 1979.

Contenuti: Epidemiology.- 1 Epidemiological investigation.- 2 Factors in the epidemiology of coeliac disease in the West of Ireland.- 3 Prevalence of coeliac disease in Derby.- 4 Incidence and age distribution of coeliac disease in North-Eastern Switzerland. Data on 500 patients between 1953 and 1978.- 5 On the incidence of coeliac disease in Austria: a study comprising a nine-year period.- 6 The changing clinical picture of coeliac disease in Lothian, Scotland.- 7 A recent reduction in the incidence of childhood coeliac disease in the West of Scotland.- 8 Recent Scandinavian data on the epidemiology of coeliac disease.- Discussion of Chapters 1–8.- Membership of the Coeliac Society of the United Kingdom.- 9 Malignant and non-malignant disease in relatives of patients with dermatitis herpetiformis and coeliac disease: a preliminary report.- Discussion of Chapter 9.- 10 On the association of coeliac disease with allergic disorders. A study of family histories of 110 families with one or two children with coeliac disease.- Discussion of Chapter 10.- 11 Epidemiological and genetic aspects of the coeliac syndrome in relation to dermatitis herpetiformis.- Discussion of Chapter 11.- 12 Coeliac disease in Asian children in the United Kingdom.- Discussion of Chapter 12.- Immunogenesis.- 13 The HLA system.- 14 Evolution and the genetics of coeliac disease.- 15 Chido and Rodgers blood groups.- 16 C4 and factor Bf polymorphisms in coeliac disease.- 17 HLA-DR antigens in coeliac disease. A population and multiple case family study.- Discussion of Chapter 17.- 18 B-cell alloantigens associated with coeliac disease in the West of Ireland.- Discussion of Chapter 18.- 19 DR-locus-controlled B-cell alloantigens in coeliac disease in The Netherlands.- Discussion of Chapter 19.- 20 The relationship of HLA-A, B status to the clinical findings and autoimmunity in coeliac disease.- Discussion of Chapter.- 21 The influence of histocompatibility genes on the pathogenesis of gluten sensitive enteropathy.- Family Studies.- 22 Coeliac disease: previous family studies.- 23 A critical analysis of HLA in coeliac family studies in Birmingham.- 24 The familial occurrence of coeliac disease.- Discussion of Chapter 24.- 25 Gluten sensitive enteropathy in Spain: genetic and environmental factors.- Discussion of Chapter 25.- 26 The familial incidence of asymptomatic coeliac disease.- Discussion of Chapter 26.- 27 Investigations of a two-locus model for coeliac disease.- Discussion of Chapter 27.- 28 Liverpool coeliac family study.- Discussion of Chapter 28.- 29 Summing up.

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Titolo: The Genetics of Coeliac Disease
Casa editrice: Springer Nature B.V. Mai 2012
Data di pubblicazione: 2012
Legatura: Taschenbuch
Condizione: Neu