Glial-Neuronal Communication in Development and Regeneration

This comprehensive volume is a contribution to a new se ries initiated by the NATO Panel on "Gell to Gell Signals in Plants and Animals". The book reflects the outcome of an NATO work­ shop and bri ngs to mi nd two im portant questions: consideri ng the mass of relevant I iteratu reavai- able, is there any necessity for a new series of books - and considering the flood of compa­ rable meetings - is there any point in workshops of this nature and their publication? In order to deal with such questions adequately, much more space would be needed than is available in a foreword. Thus, the answers must remain rather superficial and, of course, rather subjective. To simplify the issue, the question of publication can be narrowed down to two fac­ tors - the financial risk, undertaken by the publisher, and the scientific risk, borne by the editor. If the book is good (with respect to lay-out and content) it will be a success - nothing will be lost­ the people involved will enhance their reputation! We are left with the question of the usefulness of workshops. Without doubt, it is indeed a useful procedure for experts to come together, in an atmosphere of harmony, and freedom from external pressures and time limitations, to discuss a well-defined theme. Wether in agreement or disagreement, a fair and open forum can be expectet for a variety of contributions.

Glial Cell Lineages.- From Neuroepithelium to Mature Astrocytes.- Experimental Models for Astrocyte Activation and Fibrous Gliosis.- Microglia in Culture.- Molecular Properties of Peripheral Glia.- Receptors and Antigens Expressed by Glial/Neuronal Cells During Ontogenesis.- Adrenergic- and Histamine-Receptors on Cultured Astrocytes: Electrophysiological and Autoradiographic Binding Studies.- Desipramine Treated C6 Glioma Cells Express Opiate Receptors; Unmasking or Induction?.- Expression of Recognition Molecules in the Cerebellum of Young and Adult Rats.- Myelin-Associated Glycoprotein (MAG) in Chicken Neuronal Crest Derivatives, Including Neurons.- Neurone-Glia Relationship in the Retina: Localization OF GABA Uptake and Endogenous GFAP and GABA Immunoreactivities.- Developmentally Regulated Glial and Neuronal Antigens Detected by Monoclonal Antibodies.- Expression of Recognition and Adhesion Molecules at the Glial-Neuronal Cell Surface.- Biosynthesis of the Neural Cell Adhesion Molecule (N-CAM): Glial, Muscle and Neuronal Forms of N-CAM Studied in Primary Rat Cell Cultures.- Neurite Outgrowth Induced by Adhesive Proteins.- Neuronal Adhesion to Components of the Extracellular Matrix and Control of Nerve Fiber Growth.- Glial-Neuronal Interactions.- Modulation by Neuronal Signals of Energy Substrate in the Glial Cells of Leech Segmental Ganglia.- Regulation of Astrocytic High Affinity Uptake of Transmitter Amino Acids by Neuronal Signaling.- Characterization of Glial Proteins Transferred into the Squid Giant Axon.- Do Glial Cells Compete with Afferent Fibers for Apposition to the Neuronal Surface in Development and Aging of the Nervous System? A Study in the Avian Ciliary Ganglion with References to Other Neurons.- Influence on Glial/Neuronal Cells by Hormones and Gangliosides- Trophic Factors and Informational Substances.- Factors Affecting the Survival and Maturation of Nerve Cells in Culture.- Glycoconjugate Metabolism, Accretion and Release During Neurite Outgrowth in Normal and Transformed Cells of Neuronal Origin.- In Vitro Analysis of Glial-Neuronal Communication During Cerebellum Ontogenesis.- Effect of Nerve Growth Factor and cAMP Analogues on Neuronal Differentiation in PC12Cells: Studies with an Inhibitor of cAMP-Dependent Protein Kinases.- Are Phosphotyrosine-Containing Proteins Induced by Nerve Growth Factor Stimulation of PC12 Cells?.- Chromaffin Cells: Modified Neurons that are Both Targets and Storage Sites of Neuronotrophic and Neurite Promoting Factors.- Neurotrophic and Neurite Promoting Activities in Astroglial Conditioned Medium.- Neurite-Promoting Factors for Spinal Neurons.- Putative Autoregulative Growth Factor in Conditioned Medium OF Serum-Free Grown Astrocytes.- Differentiation of Astrocyte Precursors From Mouse Cerebellum.- Isolation of Two Astroglial Growth Factors from Bovine Brain; Comparison with Other Growth Factors; Cellular Localization.- Glial Cell Development and Reactivity in Reaggregating Brain Cell Culture.- Trophic and Metabolic Couplings Between Astroglia and Neurons.- Repair Mechanisms During Neuronal Regeneration.- Neural Tissue Transplants Modify Response of the Immature Spinal Cord to Damage.- Conditions for Neuronal Survival and Growth as Assessed by the Intracerebral Transplantation Technique in Lesion Models of the Adult CNS.- Hippocampal Transplants: Synaptic Organization, their Use in Repair of Neuronal Circuits and Mouse to Rat Xenografting.- A Model of Neuronal Sprouting for Examining the Role of Glia in Axonal Growth.- Comparative Studies of the Astrocytic Membrane in Regenerative and Non-Regenerative Central Nervous Systems.- Neural Tissue Transplants: Studies Using Tissue Culture Manipulations, Cell Marking Techniques and A Plasma Clot Method to Follow Development of Grafted Neurons and Glia.- Pharmacologic and Immunologic Approaches to the Problems of Posttraumatic Glial Proliferation Following CNS Damage.- Molecular Approach to the Role of Macrophages and Astrocytes in Nerve Growth and Regeneration.- Culturing of Neurons and Oligodendrocytes Bulk Isolated from the Same Brain of Young Adult Rats.- Myelination — Remyelination.- Role of Galactocerebroside in the Formation of Peripheral Myelin.- Further Characterization of the Neuronal Cell Surface Protein Mitogenic for Schwann Cells.- Galactocerebroside Expression by Non-Myelin Forming Schwann Cells.- Molecular Organization of the Cell Membrane in Normal and Pathological Axons: Relation to Glial Contact.- Oligodendrocyte Differentiation: Quantitative Studies in Primary Cultures of Dissociated Fetal Rat Brain.- Myelin Palingenesis: the Reformation of Myelin by Mature Oligodendrocytes in the Absence of Neurons.- Oligodendrocytes Ensheath Carbon Fibres and Produce Myelin in Vitro.- Oligodendrocyte Proliferation: Its Relationship to Central Nervous System Remyelination.- Myelination in the Mouse by Transplanted Oligodendrocytes.