Riassunto
The leading reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients, this all-inclusive, multidisciplinary text covers the ever-widening sphere of current cancer knowledge and clinical practice. In this new sixth edition, an outstanding editorial team from world-renowned medical centers presents a comprehensive yet manageable resource for all aspects of oncology. This text continues its leading pace with new and updated information on biology, immunology, aetiology, epidemiology, clinical trials, prevention, screening and early detection, pathology, imaging, and therapies. The 162 comprehensive chapters are organized into six parts: Cardinal Manifestations of Cancer, Scientific Foundations of Cancer, Principles of Cancer Diagnosis, Principles of Therapeutic Modalities, Principles of Multidisciplinary Management, and Cancer Management. This edition sees expanded chapters on tumour immunology, and on the theory and practice of clinical trials. Completely new chapters focus on the cardinal manifestations of cancer, targeted therapy, pregnancy and cancer, cancer and aging, central nervous system metastases, primary central nervous system tumours, bone tumours, unique pathological features of childhood cancer and special considerations for adolescents and young adults. "Cancer Medicine, Sixth Edition", features hundreds of colour and black-and-white illustrations and photographs, tables, graphs and algorithms that make this text a valuable clinical tool in recognizing characteristic appearances of both patient and tissue.
Contenuti
Part I Cardinal Manifestations
1. Cardinal Manifestations of Cancer
James F. Holland.
Part II Scientific Foundation, Section 1: Cancer Biology
2. Molecular Biology, Genomics, and Proteomics
Kornelia Polyak and Matthew Meyerson.
3. Cell Proliferation and Differentiation
Michael Andreeff, David W. Goodrich, and Arthur B. Pardee.
4. Apoptosis and Cancer
John C. Reed.
5. Growth Factors and Signal Transduction In Cancer
Anna Bafico and Stuart A. Aaronson.
6. Oncogenes
Marco A. Pierotti, Gabriella Sozzi, and Carlo M. Croce.
7. Tumor-Suppressor Genes
Ben Ho Park and Bert Vogelstein.
8. Recurring Chromosome Rearrangements in Human Cancer
Denise A. Levitan, Rita Nanda, Janet D. Rowley, and Olufunmilayo I. Olopade.
9. Biochemistry of Cancer
Raymond W. Ruddon.
10. Invasion and Metastases
Lance A. Liotta and Elise C. Kohn.
11. Tumor Angiogenesis
Judah Folkman and Raghu Kalluri.
Section 2: Cancer Immunology
12. Tumor Antigens
Hassane M. Zarour, Albert DeLeo, Olivera J. Finn, and Walter J. Storkus.
13. Tumor Markers and Immunodiagnosis
William Bigbee and Ronald B. Herberman.
14. Effectors of Immunity and Rationale for Immunotherapy
Theresa L. Whiteside and Ronald B. Heberman.
15. Tumor-Associated Immunodeficiency and Implications for Tumor Development and Prognosis
William H. Chambers, Hannah Rabinowich, and Ronald B. Herberman.
Section 3: Cancer Etiology
16. Genetic Predisposition to Cancer
Marcia S. Brose, Thomas C. Smyrk, Barbara Weber, and Henry T. Lynch.
17. Chemical Carcinogenesis
Ainsley Weston and Curtis C. Harris.
18. Hormones and the Etiology of Cancer
Brian E. Henderson, Leslie Bernstein, and Ronald K. Ross.
19. Ionizing Radiation
John B. Little.
20. Ultraviolet Radiation Carcinogenesis
James E. Cleaver and David L. Mitchell.
21. Physical Carcinogens
Morando Soffritti, Franco Minardi, and Cesare Maltoni.
22. Tumor Viruses
Robert C. Gallo and Marvin S. Reitz.
23. Herpesviruses
Jeffrey I. Cohen.
24. Papillomaviruses and Cervical Neoplasia
Christopher P. Crum and Catherine M. McLachlin.
25. Hepatitis Viruses
Max W. Sung and Swan N. Thung.
26. Parasites
Piero Mustacchi.
Section 4: Cancer Epidemiology, Prevention, and Screening
27. Cancer Epidemiology
Michael J. Thun and Ahmedin Jemal.
28. Prevention of Tobacco-Related Cancer
Paul F. Engstrom, Margie L. Clapper, and Robert A. Schnoll.
29. Nutrition in the Etiology and Prevention of Cancer
Steven K. Clinton, Edward L. Giovannucci, and Elizabeth C. Miller.
30. Chemoprevention of Cancer
Michael B. Sporn and Scott M. Lippman.
31. Cancer Screening and Early Detection
Robert A. Smith, Curtis J. Mettlin, and Harmon Eyre.
Section 5: Clinical Trials and Outcomes Assessment
32. Theory and Practice of Clinical Trials
Marvin Zelen.
33. Statistical Innovations in Cancer Research
Donald Berry.
34. Outcomes Assessment
Jane C. Weeks.
Part III Cancer Diagnosis, Section 6: Cancer Pathology
35. Principles of Cancer Pathology
James L. Connolly, Stuart J. Schnitt, Helen H. Wang, Janina A. Longtine, Ann Dvorak, and Harold F. Dvorak.
Section 7: Imaging
36. Principles of Imaging
Edward F. Patz.
36a. Imaging Cancer of Unknown Primary Site
Kitt Shaffer.
36b. Imaging Neoplasms of the Central Nervous System, Head, and Neck
Christopher J. Hurt, David M. Yousem, and Norman J. Beauchamp.
36c. Imaging Neoplasms of the Thorax
Jeremy J. Erasmus and H. Page McAdams.
36d. Imaging Neoplasms of the Abdomen and Pelvis
Haesun Choi, Evelyne Loyer, Harmeet Kaur, and Paul M. Silverman.
36e. Imaging of Musculoskeletal Neoplasms
R. Lee Cothran and Clyde A. Helms.
36f. Imaging the Breast
Lawrence W. Bassett, Karen Conner, and MS.
36g. Ultrasonography: Its Role in Oncologic Imaging
Stephanie R. Wilson.
36h. Radionuclide Imaging in Cancer Medicine
R. Edward Coleman.
36i. Perspectives in Imaging: Present and Future Prospects of Clinical Molecular Imaging
David Piwnica-Worms.
37. Interventional Radiology for the Cancer Patient
Marshall Hicks, Michael Wallace, and Sanjay Gupta.
Part IV Therapeutic Modalities, Section 8: Surgical Oncology
38. Principles of Surgical Oncology
Raphael E. Pollock and Donald L. Morton.
Section 9: Radiation Oncology
39. Principles of Radiation Oncology
Arno J. Mundt, John C. Roeske, Theodore D. Chung, and Ralph R. Weichselbaum.
40. Photodynamic Therapy of Cancer
Tayyaba Hasan, Bernhard Ortel, Anne C.E. Moor, and Brian W. Pogue.
41. Hyperthermia
Mark W. Dewhirst, Ellen Jones, Thaddeus Samulski, Zeljko Vujaskovic, Chuan Li, and Leonard Prosnitz.
Section 10: Medical Oncology
42. Principles of Medical Oncology
James F. Holland, Emil Frei, Donald W. Kufe, and Robert C. Bast.
Section 11: Chemotherapy
43. Cytokinetics
Chau Dang, Teresa A. Gilewski, Antonella Surbone, and Larry Norton.
44. Principles of Dose, Schedule, and Combination Therapy
Emil Frei and Joseph Paul Eder.
45. Preclinical and Early Clinical Development of New Anticancer Agents
Daniel D. Von Hoff and Axel-R. Hanauske.
46. Pharmacology
Mark J. Ratain and William K. Plunkett.
47. Regional Chemotherapy
Maurie Markman.
48. Drug Resistance and its Clinical Circumvention
Jeffrey Moscow, Charles S. Morrow, and Kenneth H. Cowan.
Section 12: Chemotherapeutic Agents
49. Folate Antagonists
Barton A. Kamen, Peter D. Cole, and Joseph R. Bertino.
50. Pyrimidine and Purine Antimetabolites
Giuseppe Pizzorno, Robert B. Diasio, and Yung-Chi Cheng.
51. Alkylating Agents and Platinum Antitumor Compounds
Michael Colvin.
52. Anthracyclines and DNA Intercalators/Epipodophyllotoxins/ Camptothecins/DNA Topoisomerases
Eric H. Rubin and William N. Hait.
53. Microtubule-Targeting Natural Products
Eric Rowinsky.
54. Small-Molecule Inhibitors of Protein Kinases in the Treatment of Human Cancer
Michael C. Heinrich, Charles D. Blanke, Christopher L. Corless, and Brian J. Druker.
Section 13: Biotherapeutics
55. Asparaginase
Joanne Kurtzberg, David Yousem, and Norman Beauchamp.
56. Interferons
Ernest C. Borden.
57. Cytokines: Biology and Applications in Cancer Medicine
Suhendan Ekmekcioglu and Elizabeth A. Grimm.
58. Hematopoietic Growth Factors
Razelle Kurzrock.
59. Monoclonal Serotherapy
Robert C. Bast, Christina A. Kousparou, Agamemnon A. Epenetos, Michael R. Zalutsky, Robert J. Kreitman, Edward A. Sausville, and Arthur E. Frankel.
60. Vaccines and Immunostimulants
Jeffrey Schlom and Scott I. Abrams.
Section 14: Endocrine Therapy
61. Hypothalamic and Other Peptide Hormones
Andrew V. Schally and Ana Maria Comaru-Schally.
62. Corticosteroids
Lorraine I. McKay and John A. Cidlowski.
63. Estrogens and Antiestrogens
Craig V. Jordan.
64. Aromatase Inhibitors
Aman U. Buzdar and Harold A. Harvey.
65. Progestins
Kenneth S. McCarty, Mark Nichols, and Kenneth S. McCarty.
66. Androgen Deprivation Strategies in the Treatment of Advanced Prostate Cancer
Samuel R. Denmeade and John T. Isaacs.
Section 15: Gene Therapy
67. Cancer Gene Therapy
Sunil J. Advani, Ralph R. Weichselbaum, and Donald W. Kufe.
Section 16: Bone Marrow Transplantation
68. Autologous Bone Marrow and Stem Cell Transplantation
William P. Peters, Roger Dansey, and Roy D. Baynes.
69. Hematopoietic Cellular Transplantation
Richard Champlin.
Part V Multidisciplinary Management, Section 17: Psycho-Oncology
70. Psycho-Oncology
Jimmie C. Holland and Jane Gooen-Piels.
Section 18: Oncology Nursing
71. Principles of Oncology Nursing
Paula Trahan Rieger and Connie Henke Yarbro.
Section 19: Cancer Rehabilitation Medicine
72. Principles of Cancer Rehabilitation Medicine
Kristjan T. Ragnarsson and David C. Thomas.
Section 20: Multidisciplinary Management
73. Principles of Multidisciplinary Management
James F. Holland, Emil Frei, Donald W. Kufe, Robert C. Bast, Raphael E. Pollock, and Ralph R. Weichselbaum.
74. Cancer and Pregnancy
Richard L. Theriault, Karin M.E.H. Gwyn, and Gabriel N. Hortobagyi.
75. Cancer and Aging
Arti Hurria, Hyman B. Muss, and Harvey J. Cohen.
76. Complementary and Alternative Cancer Therapies
Barrie R. Cassileth and Andrew Vickers.
Section 21: Pain and Palliation
77. Palliative Care
Natalie Moryl, Alan C. Carver, and Kathleen M. Foley.
78. Management of Cancer Pain
Alan C. Carver and Kathleen M. Foley.
Section 22: Societal Oncology
79. Ethics in Oncology
Ezekiel J. Emanuel and Steven Joffe.
80. Cancer and the Law
Joseph M. Taraska.
81. The Government and Cancer Medicine
Anna D. Barker and Hamilton Jordan.
82. Clinical Oncology in a Changing Healthcare Environment
Martin N. Raber and Joseph P. Bailes.
Part VI Cancer Management, Section 23: Central Nervous System
83. Primary Neoplasms of the Central Nervous System
Edward Pan and Michael D. Prados.
84. Brain Metastases
Lisa M. DeAngelis and Jerome B. Posner.
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