HPLC-UV Method development for Fixed Dose Pharmaceutical Formulations (Paperback)

Lingua: inglese

Editore: LAP Lambert Academic Publishing, 2026

6209779719 / 9786209779718

Da: Grand Eagle Retail, Bensenville, IL, U.S.A.Grand Eagle Retail

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Paperback. Estimation of imeglimin hydrochloride in human plasma by HPLC-UV. The estimation of drugs by RP-HPLC (reverse phase chromatography) was chosen since it is advised for use with ionic and mild to non-polar compounds. Simple, specific, and superior in terms of efficiency, stability, and reproducibility is reverse phase chromatography. For the separation of imeglimin, the C18 column 250 x 4.6 mm, 5 um particle size was chosen. In the mobile phase, various solvent solutions were tested and combined for optimum performance. Imeglimin hydrochloride (4 ug/ml) in buffer, pH 4 for Acetonitrile: Water (70:30), a concentration range (8-40 and 0.5-4 ug/ml) displaying excellent peak and a sizable resolution level. Having the mobile phase run at 1ml/min, photodiode array detectors were used to detect both analytes at 215 nm. The method was validated in different concentration ranges in human plasma. Imeglimin inter and intra-run precision was measured at less than 3.60% and had an accuracy of less than 1.869%. imeglimin in human plasma was validated by linearity, recovery matrix, and stability. The retention time of IMEG is 4.8 minutes in plasma. Suggested method denotes that it is cost-effective This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Codice articolo 9786209779718

Titolo
HPLC-UV Method development for Fixed Dose Pharmaceutical Formulations (Paperback)
Autore
Sonia Yadav
Editore
LAP Lambert Academic Publishing
Anno di pubblicazione
2026
Condizione
new
Rilegatura
Paperback
Lingua
inglese
ISBN 10
6209779719
ISBN 13
9786209779718

Grand Eagle Retail

Bensenville, IL, U.S.A.

Venditore con 5 stelle

Venditore AbeBooks dal 12 ottobre 2005

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