Handbook of Downstream Processing

E. Goldberg

ISBN 10: 0751403644 / ISBN 13: 9780751403640

Editore: Springer Netherlands, Springer Netherlands Okt 1996, 1996

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Neuware -The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous How should the optimum process design be developed Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 756 pp. Englisch.

Codice articolo 9780751403640

Dati bibliografici

• Titolo: Handbook of Downstream Processing
• Editore: Springer Netherlands, Springer Netherlands Okt 1996
• Data di pubblicazione: 1996
• Lingua: Inglese
• ISBN 10: 0751403644
• ISBN 13: 9780751403640
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 241 L x 160 A x 45 P (millimetri) 241 millimetri di larghezza per 160 millimetri di altezza per 45 millimetri di profondità
• Peso: 1285 grammi

Descrizione articolo

Riassunto

The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized­ in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Recensione

`... the book offers a great deal of useful information for readers.'
Angewandte Chemie