Hematology: Basic Principles and Practice

This renowned textbook comprehensively covers all aspects of clinical and experimental haematology. Thoroughly revised throughout-including contributions by many new authors-the new 3rd Edition applies the latest scientific information to the clinical diagnosis and management of haematologic diseases.

Part I: Mollecular and Cellular Basis of Hematology. Anatomy and Physiology of the Gene. Protein Synthesis and Intracellular Sorting. Protein Architecture: Relationship of Form and Function. Membrane Biology. Cell Adhesion. Cellular Regulatory and Control Mechanism. Part II: Immunologic Basis of Hematology. Overview of the Immune System (including Compartmentalization of the Immune Response). Generation of B-cells. T-cell Immunity. Regulation of Activation of B and T-cells. Tolerance and Autoimmunity.
Part III: Biology of Stem Cells and Disorders of Hematopoiesis. Stem Cell Model of Hematopoiesis. Anatomy and Physiology of Hematopoiesis. Growth Factors and the Control of Hematopoiesis. Biology of Erythropoiesis, Erythroid Differentiation and Maturation. Granulopoiesis and Monocytopoiesis. Thrombocytopoiesis. Inherited Forms of Bone Marrow Failure. Aplastic Anemia. Paroxysmal Nocturnal Hemoglobinuria. Pure Red Blood Cell Aplasia.
Part IV: Red Blood Cells. Pathobiology of the Red Cell. Approach to the Adult and Child with Anemia. Anemia of Chronic Diseases. Erythrocytosis. Disorders of Iron Metabolism: Iron Deficiency and Overload. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias. Megaloblastic Anemias. Thalassemia Syndromes. Sickle Cell Disease. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias. Enzymopathies. Red Cell Membrane Disorders. Autoimmune Hemolytic Anemias. Extrinsic Nonimmune Hemolytic Anemias.
Part V: Host Defense and Its Disorders. Immunoglobulins: Structure, Function, and Uses. Complement Biology. Neutrophil Structure and Function. Monocyte and Macrophage Development and Function. Eosinophils and the Hypereosinophilic Syndrome. Disorders of the Phagocyte Function. Disorders of the Lymphocyte Function. Histiocytic Syndromes. Lysosomal Storage Disease. Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases. Spleen and Its Disorders. Systemic Mastocytosis.
Part VI: Hematologic Malignancies. Cytogenetics and Neoplasia. Molecular Basis of Neoplasia. Pharmacology of Antineoplastic Agents, Drug Resistance, and the Future. Clinical Application of Cytokines and Biologic Response Modifiers. Pathobiology of Human Acute Myeloid Leukemia. Clinical Manifestations of Acute Myeloid Leukemia. Therapy for Acute Myeloid Leukemia. Congenital Leukemias and Acute Myeloid Leukemia in Children. Pathobiology of Acute Lymphocytic Leukemia. Clinical Manifestations of Acute Lymphocytic Leukemias in Children. Therapy for Acute Lymphocytic Leukemia in Children. Acute Lymphocytic Leukemia in Adults. Myelodysplastic Syndromes. Polycythemia Vera. Chronic Myeloid Leukemia. Agnogenic Myeloid Metaplasia. Primary Thrombocythemia. Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children. Pathobiology of Lymphoproliferative Disease. Pathology and Histogenesis of Hodgkin Disease. Hodgkin Disease: Clinical Manifestations, Staging, and Therapy. Non-Hodgkin Lymphomas: Pathologic Features and Clinical Correlations. Clinical Manifestations and Staging of and Therapy for Non-Hodgkin Lymphomas. Childhood Lymphomas. Chronic Lymphocytic Leukemia. Hairy Cell Leukemia. Cutaneous T-Cell Lymphomas. AIDS-Associated Lymphomas. Multiple Myeloma andOther Plasma Cell Disorders. Amyloidosis. Atypical Immune Proliferations. Clinical Approach to Infections in the Compromised Host. Nutritional Support of Patients with Hematologic Malignancies. Psychosocial Care in Hematologic Disease. Pain Management and Antiemetic Therapy in Hematologic Disorders. Indwelling Access Devices.
Part VII: Transplantation. Introduction. Results of Allogeneic Transplantation for Non-Malignant Disorders. Results of Allogeneic Transplantation for Malignant Disorders. Results of Autologous Transplantation for Hematologic Malignancies. Clinical Results of Autologous Transplantation for Solid Tumours. Results of Unrelated Donor Transplantation Therapy. Clinical Results of Umbilical Cord Blood Transplantation. Preparative Regimens. Practical Aspects of Stem Cell Collection. Graft vs. Host Disease and Graft vs. Leukemia. Graft Engineering to Enhance Engraftment, Reduce Graft vs. Host Disease and Provide Graft vs. Tumour Effect. Gene Therapy for Hematologic Disorders. Experimental CellTherapy. Prevention and Treatment of Transplant Complications.
Part VIII: Hemostasis and Thrombosis. Megakaryocyte and Platelet Structure. Molecular Basis of Platelet Function. Biochemistry of Platelet Activation. The Blood Vessel Wall. Molecular Basis ofBlood Coagulation. Molecular and Cellular Basis of Fibrinolysis. Regulatory Mechanisms in Hemostasis: Natural Anticoagulants. Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Purpura. Laboratory Evaluation of Hemorrhagic Disorders. Structure, Biology and Genetics of Factor VIII. Biochemistry of Factor IX and Molecular Biology of Hemophilia B. Clinical Aspects and Therapy of Hemophilia. Inhibitors in Hemophilia. Factor XI and Other Clotting Factor Deficiencies. Disorders of Fibrinogen. Structure, Biology, and Genetics of von Willebrand Disease. Clinical Aspects and Therapy of von Willebrand Disease. Vitamin K: Metabolism and Disorders. Inhibitors of Blood Coagulation. Disseminated Intravascular Coagulation. Hemostatic Defects Associated with Dysproteinemias. Neonatal Hemostatic Disorders. Hypercoagulable States. Oral Anticoagulant Therapy. Heparin. Fibrinolytic Therapy: Indications and Management. Venous Thromboembolism. Arterial Thromboembolism. Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Post-Transfusion Purpura. Thrombocytopenia Due to Decreased Platelet Production. Thrombotic Thrombocytopenia Purpura and the Hemolytic Uremic Syndrome. Thrombocytopenia Due to Platelet Destruction and Hyperplenism. Hereditary Disorders of Platelet Function. Acquired Disorders of Platelet Function.
Part IX: Transfusion Medicine. Human Blood Group Antigens and Antibodies. Section I: Carbohydrate Determinants. Section II: Protein Determinants. Human Platelet Antigens. Leukocyte and HLA Antigens and Antibodies. Principles of Red Blood Cell Transfusion. Principles of Platelet Transfusion Therapy. Principles of White Blood Cell Transfusion. Transfusion of Plasma Derivatives: Fresh Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins. Preparation of Plasma-Derived and Recombinant Human Plasma Proteins. Transfusion Principles for Congenital Coagulation Disorders. Hemapheresis and Cellular Therapy. Transfusion Reactions. Transfusion-Transmitted Diseases. Autologous Blood Transfusion. Transfusion in Hematopoietic Stem Cell and Solid Organ Transplantation. Red Cell Substitutes.
Part X: Consultative Hematology. Hematologic Complications of Liver Disease and Alcoholism. Hematologic Complications of Renal Disease. Hematologic Aspects of Pregnancy. Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis. Hematologic Manifestation of Childhood Illness. Hematologic Problems in Patients with Cancer and Chronic Inflammatory Disorders. Hematologic Manifestations of Infectious Disease. Hematologic Manifestations of AIDS.
Part XI: Special Tests and Procedures. Preparation and Interpretation of Peripheral Blood Smears and Bone Marrow. Automated Analysis of Blood Cells. Laboratory Detection of Hemoglobinopathies and Thalassemias. Antenatal Diagnosis of Hematologic. Electrophoretic and Immunochemical Analysis of Human Immunoglobulins. Use of Molecular Techniques in the Analysis of Hematologic Diseases.