Humoral Immunity in Neurological Diseases

D. Karcher

ISBN 10: 1468410059 / ISBN 13: 9781468410051

Editore: Springer US, Chapman And Hall/CRC Aug 2012, 2012

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This item is printed on demand - it takes 3-4 days longer - Neuware -The Nato Advanced Study Institute on Humoral Immunity in Neurological Diseases became possible thanks to the active help of many people. I will not mention our colleagues at the neuroche mical laboratory of the Born-Bunge Foundation : it was our common job. But I wish to thank : - the Nato and Dr. Kester for their aid, support and gene rosity, - the Belgian Ministry of Foreign Affairs and Secretary-ge neral Mr. Grandry for their help and assistance in esta blishing valuable contacts with many foreign countries, - the Belgian Ministry of Culture for their grant, - the National Fund for Scientific Research and the Belgian Society of Neurology for their financial support. Substantial help came from the Universitaire Instelling Ant werpen : not only financiall~ but by allowing members of their staff to assist us 'in many ways. The Belgian Friends of the Weizmann Institute and the Belgian Medical Care for Israel helped invite some participants, and many firms made a contribution to our organization. To all of them our warmest thanks. 688 pp. Englisch.

Codice articolo 9781468410051

Dati bibliografici

• Titolo: Humoral Immunity in Neurological Diseases
• Editore: Springer US, Chapman And Hall/CRC Aug 2012
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 1468410059
• ISBN 13: 9781468410051
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 254 L x 178 A x 37 P (millimetri) 254 millimetri di larghezza per 178 millimetri di altezza per 37 millimetri di profondità
• Peso: 1272 grammi

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Riassunto

The Nato Advanced Study Institute on Humoral Immunity in Neurological Diseases became possible thanks to the active help of many people. I will not mention our colleagues at the neuroche­ mical laboratory of the Born-Bunge Foundation : it was our common job. But I wish to thank : - the Nato and Dr. Kester for their aid, support and gene­ rosity, - the Belgian Ministry of Foreign Affairs and Secretary-ge­ neral Mr. Grandry for their help and assistance in esta­ blishing valuable contacts with many foreign countries, - the Belgian Ministry of Culture for their grant, - the National Fund for Scientific Research and the Belgian Society of Neurology for their financial support. Substantial help came from the Universitaire Instelling Ant­ werpen : not only financiall~ but by allowing members of their staff to assist us 'in many ways. The Belgian Friends of the Weizmann Institute and the Belgian Medical Care for Israel helped invite some participants, and many firms made a contribution to our organization. To all of them our warmest thanks.

Contenuti

I Spontmeous and Experimental Diseases.- A. Multiple Sclerosis.- Cellular Immunology in Multiple Sclerosis: a) Introduction and History.- Cellular Immunology in Multiple Sclerosis: b) Response to Several Viruses.- Cellular Immunology in Multiple Sclerosis: c) Studies on Immune Regulatory Cells.- Humoral Immunity in Disease with Special Reference to Multiple Sclerosis.- Cellular Immune Function to Measles Antigen in Normal Subjects and Multiple Sclerosis—Skin Testing with Autologous CSF and Other Antigens in Multiple Sclerosis.- Cases of Acute Measles Infection in Multiple Sclerosis Patients.- Pathogenetic Considerations in Multiple Sclerosis: Is MS a Chronic Variant of Postinfectious Encephalomyelitis ?.- Heterogeneous Humoral Autoimmune Response in Multiple Sclerosis.- B. Subacute Sclerosing Panencephalitis.- Subacute Sclerosing Panencephalitis.- Comparative Neuropathology of Subacute Sclerosing Panencephalitis.- Cross-Idiotypic Specificity among Immunoglobulins in Subacute Sclerosing Panencephalitis and Multiple Sclerosis.- The Virological State in Subacute Sclerosing Panencephalities.- Cellular Immunity in Subacute Sclerosing Panencephalitis.- Progressive Rubella Panencephalitis.- C. Genetic Implications.- Multiple Sclerosis and the HLA Determinants.- HLA and Multiple Sclerosis: Genetic Considerations..- Familial Aspects of Multiple Sclerosis: a Rational Prophylactic Therapy.- D. Animal Diseases.- Distribution of Scrapie Infectivity in Various Mouse Tissues at Early Times after Infection.- Immunoglobulin G Levels in the Sera of Herdmick Sheep with Natural Scrapie.- Visna in Sheep.- Old Dog Encephalitis: A Clinical and Serological Study.- Experimental Murine Autoimmune Encephalomyelitis.- II Restricted Heterogeneity (Oligoclonal Reaction).- A. Cerebrospinal Fluid Methodology.- Isoelectric Focusing and Crossed Immunoelectro-focusing of CSF Proteins—Especially Immunoglobulins.- Study of Oligoclonal CSF by new Immunofixation Techniques Following Electrophoresis on Cellulose Acetate Gel.- Radioimmunoassay of Immunoglobulins in Cerebrospinal Fluid.- Measurement of Blood/CSF Permeability Coefficients and of Intrathecal Synthesis of IgG by Capillary Isotachophoresis.- Study on the Iinmunoglobulins (IgG, IgA and IgM) in the Cerebrospinal Fluid and Serum in Cases of Suppurative Meningitis and Viral Encephalitis.- Viral Antibody and Protein Studies of Cerebrospinal Fluid: Diagnostic Usefulness in Multiple Sclerosis.- The Clinical Significance of Immunoglobulin G (IgG) Determinations in the CSF öf Multiple Sclerosis Patients.- Determination of IgM in the Cerebrospinal Fluid by Particle Counting Immnoassay (PACIA).- Local and General Immunity in CNS Diseases.- Nucleic and Viral Antibodies in Serum and CSF of MS Patients.- Problems with Qualitative CSF Antibody Tests.- Immunocytological CSF Alterations and Brain Tumors.- Study of Humoral Immunity in Cerebrospinal Fluid of Patients Infected with Schistosomiasis.- B. IgG Restricted Heterogeneity.- Restricted Heterogeneity of the IgG in Neurology.- Oligoclonal Immune Responses in the Central Nervous System (CNS) in Connection with Virus Infections and CNS Diseases of Unknown Etiology.- Oligoclonal Virus Antibodies in Healthy Adults and Neurological Patients.- C. Immunochemistry.- Immunoglobulin Structure and Function: Idiotypy and the Oligoclonal Response.- Structural Studies of Immunoglobulins from Patients Affected by Subacute Sclerosing Panencephalitis.- Insights Gained from the Study of Homogeneous Rabbit Antibodies.- Circulating Immune, Complexes in Neurological Disorders.- D. Viral Antigens.- Partial Purification of Multiple Sclerosis Specific Antigens.- Characterization of Measles Specific Proteins Synthesized from Acutely and Persistently Infected Cells.- New Polypeptides in Measles Virus Infected Vero Cells.- The Fate of Antigen-Antibody Complexes on Measles Virus-Induced Giant Cells.- Induction of Infectious Virus and Viral Surface Antigen in Vero Cells Persistently Infected with Junin Virus.- E. Central Nervous System Antigens.- Antibody to Oligodendroglia.- Brain Specific Proteins in Cerebrospinal Fluid.- Loss of a Brain-Specific Antigen (Alpha2 Glycoprotein) in Human Glial Tumors.- Neuroblastoma Cytoskeleton shown by Immunofluorescence.- In Vitro Assessment of the Cell-Mediated Immune Response Towards Human Gliomas.- Macrophage-Specific Antigens.- F. Nervous System Response.- Oligoclonal IgG Bands and Measles Antibodies in Multiple Sclerosis (MS) CSF and Brain Extracts.- Characterization of the Humoral Immune Response Within the CNS by Immunofixation.- Effects of Serum Factors Upon Myelin Organization in Organotypic Cultures of Nervous Tissue.- The Enhancing Effect of Multiple Sclerosis Brain Homogenates on the Active E Rosette Forming Lymphocytes.- Further Studies on the Elution of Immunoglobulin from Multiple Sclerosis Brain.- Interactions of Vaccinia Virus with the Myelin Membrane.- Functional Impairment of Neuronal Model Cells Induced by Persistent Viral Infection.- Active T Cells in Blood and CSF in MS and Controls.- Isolation and Characterization of the T Cell Receptor for the Basic Encephalitogenic Protein in EAE.- The Influence of the T Immune System on the Appearance of Homogeneous Immunoglobulins in Man and Experimental Animals.- Regulatory Interactions Between Cells in Immune Responses.- Inhibiting Factor: General Review.- B Lymphocyte Function in SSPE: Is there Lack of Suppressor Cells ?.- Topic III Therapeutic Considerations.- Pathogenesis of Multiple Sclerosis Lesion: Implications for Therapy.- Immunologic Factors in the Suppression of Experimental Allergic Encephalomyelitis: Relevance to Multiple Sclerosis.- Four Laboratory Methods for the Diagnosis of Multiple Sclerosis: A Programme for Treatment and Possible Prophylaxis.- Suppression of Experimental Allergic Encephalomyelitis with a Synthetic Copolymer-Relevance to Multiple Sclerosis.- Intrathecal Methotrexate in Multiple Sclerosis.- Remissions and Exacerbations during Cyclophosphamide and Steroid Therapy in a Case of Neuromyelitis Optica.- Intrathecal Administration of Interferon in Multiple Sclerosis Patients ?.- Varia—Other Diseases.- Renal and Skin Biopsy Findings in Amyotrophic Lateral Sclerosis.- Some Muscular Changes in Patients with Schistosomiasis.- Immunological Deficiency in the Down Syndrome: Importance of the Age Factor.- Conclusions.- Participants.