Hypertrophic Cardiomyopathy

This extensively updated textbook provides a comprehensive review of hypertrophic cardiomyopathy (HCM), the most common genetic disorder of the heart characterized by dysfunctional contractility at the sarcomere level. The disease produces abnormal and often focal hypertrophy on a macroscopic level that further impairs cardiac performance and may lead to life-threatening arrhythmias. There have been vast changes in the understanding and management of the disease in recent years, in addition to increased awareness and prevalence. Accordingly, HCM Centers of Excellence have rapidly grown across the world that are in need of detailed information on the topic.  This edition provides a practical yet comprehensive approach to both diagnosis and management, establishing evidence-based best practice for all scenarios.

Hypertrophic Cardiomyopathy provides readers with key points and critical clinical pearls to assist them in managing patients. Every chapter has been updated to reflect the huge changes across the topic over the past 5 years. Each chapter is supplemented by a series of relevant instructional multiple choice questions and their solutions are included in the supplemental FlashCards. All aspects of treatment are covered – traditional and novel medications, pacemakers and defibrillators, and invasive septal reduction therapy (both surgical myectomy and alcohol septal ablation) – in addition to genetics, family screening, lifestyle concerns and athletic screening. Nuanced areas such as HCM in pregnancy or in the critical care unit, or the approach to HCM and hypertension, are also addressed.  The practical approach has been reinforced with an expanded emphasis on creating a Center of Excellence, how to facilitate the multi-disciplinary approach, and on real-world case-based reviews and discussions.

Written by experts across the globe, this is an essential textbook for cardiology professionals from trainee to board-certified physician, including important information for interventional cardiologists, cardiac surgeons, cardiac imagers, critical care physicians, sports medicine physicians, genetic counsellors and electrophysiologists.

Srihari S. Naidu MD, MSCAI, FACC, FAHA, Editor of Hypertrophic Cardiomyopathy is a Professor of Medicine at New York Medical College, and Director of the Hypertrophic Cardiomyopathy Center and Cardiac Catheterization Laboratories at Westchester Medical Center Health Network in Valhalla, New York. He completed training in internal medicine at New York Presbyterian Hospital - Cornell Medical Center and general and interventional cardiology at the University of Pennsylvania Medical Center.

A recognized expert in the management of patients with Hypertrophic Cardiomyopathy in general, and the minimally-invasive alternative to open heart surgery alcohol septal ablation in particular, Dr. Naidu runs one of the largest, comprehensive, multi-disciplinary Hypertrophic Cardiomyopathy Centers of Excellence and has managed over 3000 patients with the disease. The author of over 250 original manuscripts and 4 books, including the children’s book “Lindsay’s Big Heart”, Dr. Naidu is renowned throughout the United States and Europe for his work on Hypertrophic Cardiomyopathy and Interventional Cardiology, including running a live national proctoring course on the alcohol septal ablation technique.

A nationally regarded cardiologist, Dr. Naidu serves on several committees within the American College of Cardiology (ACC) and rose to Board Member of its Board of Governors from 2021-2024.  He has co-authored or chaired 6 national guidelines and consensus statements, including two on Hypertrophic Cardiomyopathy, for the American Heart Association and the American College of Cardiology.  Dr. Naidu is a Former Trustee of the Society for Cardiovascular Angiography and Interventions (SCAI) and currently serves as its President from 2025-2026. Within SCAI, he founded the Emerging Leader Mentorship (ELM) Program, an executive leadership track for promising early career interventional cardiologists, and was instrumental in creating a universal definition for cardiogenic shock, now the standard around the world. A graduate of Brown University for both college and medical school, Dr. Naidu is Past President of the Brown Medical School Board of Directors and Trustee Emeritus of the Brown University Corporation, Brown’s highest governing body.