The Immune Synapse as a Novel Target for Therapy (Progress in Inflammation Research)

ISBN 10: 3764382953 / ISBN 13: 9783764382957

Editore: Birkhäuser, 2007

In. Codice articolo ria9783764382957_new

Riassunto:

This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance induction; and mechanisms maintaining dominant tolerance.

Dalla quarta di copertina:

The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell APC junction. It plays an essential role in the control and nature of the immune response.

In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy.

This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area.

Dati bibliografici

Titolo: The Immune Synapse as a Novel Target for ...
Casa editrice: Birkhäuser
Data di pubblicazione: 2007
Legatura: Rilegato
Condizione: New