Implications of the Blood-Brain Barrier and Its Manipulation : Volume 1 Basic Science Aspects

Lingua: inglese

Editore: Springer Us, 1989

0306426285 / 9780306426285

Da: Buchpark, Trebbin, GermaniaBuchpark

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Zustand: Sehr gut | Seiten: 434 | Sprache: Englisch | Produktart: Bücher | Understanding the structure and function of the blood-brain barrier (BBB) and recogniz­ ing its clinical relevance require a concert of scientific disciplines applied from a view­ point of integrative physiology rather than from only molecular or analytical approaches. It is this broad scope that is emphasized in this book. In my opinion, four original contributions define the field as it exists today. The first, a monograph by Broman,1 entitled The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions, was the model for many subsequent clinical and 3 experimental studies on BBB pathology. Second, experiments by Davson, summarized in his book entitled Physiology of the Ocular and Cerebrospinal Fluids, indicated that passive entry of nonelectrolytes into brain from blood is governed largely by their lipid 4 solubility. This research supported the original suggestion by Gesell and Hertzman that cerebral membranes have the semipermeability properties of cell membranes. The modem era of the barrier was introduced with the 1965 paper by Crone,2 entitled "Facilitated transfer of glucose from blood to brain tissue. " This paper identified stereospecific, facilitated transport of glucose as part of a system of regulatory barrier properties at a time when only a barrier to passive diffusion had been contemplated. Finally, the 1967 paper by Reese and Kamovsky, 11 entitled "Fine structural localization of a blood-brain barrier to exogenous peroxidase," sited the barrier at the continuous layer of cerebrovascular endothelial cells, which are connected by tight junctions.…

Codice articolo 3021484/202

Titolo
Implications of the Blood-Brain Barrier and Its Manipulation : Volume 1 Basic Science Aspects
Autore
Unbekannt
Editore
Springer Us
Anno di pubblicazione
1989
Condizione
Sehr gut
Rilegatura
Rilegato
Lingua
inglese
ISBN 10
0306426285
ISBN 13
9780306426285
Cataloghi dei venditori
Bücher

Buchpark

Trebbin, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 30 settembre 2021

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 60 a 60 giorni lavorativiDa 60 a 60 giorni lavorativi
Primo articoloEUR 105,00EUR 130,00
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