The Inflammasomes

Isabelle Couillin

ISBN 10: 3034803435 / ISBN 13: 9783034803434

Editore: Springer Basel, Springer Basel Nov 2013, 2013

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Neuware -The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1¿ and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Codice articolo 9783034803434

Dati bibliografici

• Titolo: The Inflammasomes
• Editore: Springer Basel, Springer Basel Nov 2013
• Data di pubblicazione: 2013
• Lingua: Inglese
• ISBN 10: 3034803435
• ISBN 13: 9783034803434
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 235 L x 155 A x 14 P (millimetri) 235 millimetri di larghezza per 155 millimetri di altezza per 14 millimetri di profondità
• Peso: 371 grammi

Descrizione articolo

Riassunto

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1? and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.