Infusion Chemotherapy - Irradiation Interactions: Principles and Applications to Organ Salvage and Prevention of Second Primary Neoplasms, 1e

In this volume, Drs. Rosenthal and Rotman have assembled a series of chapters authored by well recognized experts, with a unifying theme of exploring the scientific basis of chemotherapy and irradiation therapy. Clinical significant synergistic therapeutic interactions between chemotherapy and irradiation therapy are highlighted. The reader is provided with a concise and readily understandable overview of the theoretical and experimental basis for irradiation-chemotherapy interactions in the first chapter, co-authored by the editors. Subsequent chapters carefully address the pharmacokinetics of radiosensitizing agents, and explore the optimization of schedules for infusional therapy with concomitant radiation. Highlights of this volume include several chapters which provide useful overviews of the newest and most promising molecular approaches to cancer treatment: apoptosis as a target of therapeutic development; use of antiangiogenesis agents in cancer treatment; gene therapy and its applications to chemo-radiation therapy of cancer; and tumor suppression gene inactivation by SV40 mediated transformation.

Foreword. Preface. List of contributors.

Section I: Modulation of Radiotherapy by Biological and Chemotherapeutic Agents.

Infusion chemotherapy-irradiation interactions: an overview (C.J. Rosenthal, M. Rotman). Optimal scheduling of chemo-radiotherapy regimens (J. Lokich). Retinoids and cytokines in combination with ionizing radiation in squamous cell carcinomas - preclinical and clinical results (W. Hoffmann, M. Bamberg and H.P. Rodemann). Mechanisms of interaction between 5-fluorouracil and radiation: implications for continuous infusion chemotherapy (J.E. Tepper, A.W. Blackstock). Early clinical trials using platinum compounds as radiosensitizers (E. Boven). cis-Dichlorodiammine platinum(II) given in low-dose continuous infusion with concurrent radiotherapy to patients affected by inoperable lung carcinoma: a pharmacokinetic approach (F. Morazzoni et al.). Infusional schedules of platinum compounds and 5-fluorouracil in the chemoradiotherapy of solid tumors (G. Grecchi et al.). Hypoxia directed drugs: use with irradiation (S. Rockwell). Interaction of mitomycin C by continuous intravenous infusion and radiation in the treatment of colon carcinoma metastic to the liver: evidence for a synergistic effect (C.J. Rosenthal et al.). Concurrent paclitaxel and radiation therapy for solid tumors (H. Choy). The paclitaxel module: phase I and pharmacokinetic study of 96 h paclitaxel (W.H. Wilson). Paclitaxel by protracted infusion with concomitant radiation therapy: phase I study (C.J. Rosenthalet al). Doxorubicin as radiation potentiator: concurrent doxorubicin and radiation therapy interaction and its clinical applications (L-T. Wu).

Section II: Organ Salvage after Treatment with Irradiation and Concomitant Infusion Chemotherapy in Locally Advanced Malignant Tumors.

Is organ salvage in advanced disease possible? (M. Tubiana). Preservation of structure and function in epidermoid cancer of the anal canal (B.J. Cummings). Infusional chemoradiation in the conservation management of rectal cancer (T.A. Rich). Treatment of advanced bladder carcinoma with concomitant infusion of 5-fluorouracil and irradiation (H. Aziz, M. Rotman). Combined modality therapy for patients with cancer of the esophagus (H. Ali, M. Al-Sarraf). Head and neck cancer. The North American experience: moving towards organ preservation (S.G. Taylor). Preserving the head and neck anatomy while eradicating neoplastic cells: the European experience. (M. Merlano, G. Numico). Nasopharyngeal carcinoma curability by combined radiation-chemotherapy (K.N. Choi et al). Neo-adjuvant organ-preserving chemotherapy in the management of locally advanced oral cavity and oropharynx cancer: a quantitative evaluation of organ preservation and clinical response (G. Mantovani et al.). Combined radiotherapy and intra-arterial chemotherapy for advanced cancer of the oropharynx (L. PetruZelka et al.). Neo-adjuvant (primary) organ-preserving chemotherapy in the management of locally advanced laryngeal carcinoma: larynx preservation and clinical response (G. Mantovani et al.). In-field locally relapsed head and neck tumors treated with re-irradiation enhanced by simultaneous low-dose cisplatin (F. Lonardi et al.). Non-resectable non-small-cell lung carcinoma: continuous infusion of cisplatin and concurrent radiotherapy plus adjuvant surgery (A.V. Bedini et al.). Chemoradiation for gynecological cancers (M.J. John). Multimodality treatment for adult advanced soft tissue sarcomas: results of combined radio-chemotherapy (R. Palumbo et al.).

Section III: Future Directions: Molecular Biology Advances - Potential Clinical Applications to Chemo-Radiation.

Apoptosis as a target for chemotherapeutic drug development (R.W. Craig, A. Eastman). Potential of antiangiogenic agents in systemic therapy for non-small cell lung cancer (R.S. Herbst, B.A. Teicher). Gene therapy: its interactions with chemotherapy (R.J. Cristiano et al.). Cellular targets in SV40-mediated transformation (J.A. Decaprio).

Section IV: Chemo-Radiation Induced Carcinogenesis.

Mechanisms of mammalian cell mutagenesis by ionizing radiation and chemical agents (B.S. Rosenstein). Chemo-radiation induced carcinogenesis: the bone marrow transplant model (B. Shank).

Section V: Advances in Cancer Chemo-Prevention

Chemoprevention of lung cancer (B.S. Glisson et al.). Testing the worth of antiestrogens to prevent breast cancer (M. Morrow, V.C. Jordan). Activity of retinoids, interferons and tamoxifen and their association in human breast cancer (S. Toma et al.). Aspirin and other prostaglandin inhibitors for the prevention of colon cancer (K. Krishnan, M.T. Ruffin IV and D.E. Brenner). Omeprazole and clarithromycin for Helicobacter pylori eradication for the prevention of gastric carcinoma (C.B. Vaughn et al.).

Section VI: Computer Technology in Research and Clinical Practice.

The use of computer technology in oncologic research and practice (E.P. Ambinder).

Subject index.