Integration of Metabolism, Energetics, and Signal Transduction

Robert K. Ockner

ISBN 10: 0306484714 / ISBN 13: 9780306484711

Editore: Springer US, Springer US Apr 2004, 2004

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This item is printed on demand - Print on Demand Titel. Neuware -Complex and unexplained phenomena tend to foster unorthodox perspectives. This publication is an example, as is a prior publication that emphasized the concept that intermediary metabolism might play a significant and determining role in hepatocyte proliferation and 1 tumorigenesis. Formulation of this hypothesis was based on an attempt to clarify several poorly understood phenomena; including the observations: 1) that xenobiotic peroxisome proliferators such as the fibrate hypolipidemic agents induce hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen storage disease type I (glucose-6-phosphatase deficiency); and 3) that in this same syndrome, administration of glucose exerts an anti-tumor effect. Fatty acid and glucose metabolism are tightly linked in a we- established and profoundly inportant interplay. This connection, together with the fact that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis reflects inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, suggested the possibility that regulation of fatty acid metabolism could prove to be a pivotal determinant in the control of cell growth. In 1993, the year in which the paper cited above was published, insight into the importance of growth factors and signal transduction pathways in cell cycle regulation was increasing rapidly, but metabolic and energetic aspects of cell proliferation had attracted relatively little attention. Despite this, the concept seemed inescapable that the two seemingly distinct and unrelated determinants ¿ signal transduction and metabolism ¿ were integrally linked.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 416 pp. Englisch.

Codice articolo 9780306484711

Dati bibliografici

• Titolo: Integration of Metabolism, Energetics, and Signal Transduction
• Editore: Springer US, Springer US Apr 2004
• Data di pubblicazione: 2004
• Lingua: Inglese
• ISBN 10: 0306484714
• ISBN 13: 9780306484711
• Rilegatura: Buch
• Condizione: Neu

Descrizione articolo

Riassunto

Complex and unexplained phenomena tend to foster unorthodox perspectives. This publication is an example, as is a prior publication that emphasized the concept that intermediary metabolism might play a significant and determining role in hepatocyte proliferation and 1 tumorigenesis. Formulation of this hypothesis was based on an attempt to clarify several poorly understood phenomena; including the observations: 1) that xenobiotic peroxisome proliferators such as the fibrate hypolipidemic agents induce hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen storage disease type I (glucose-6-phosphatase deficiency); and 3) that in this same syndrome, administration of glucose exerts an anti-tumor effect. Fatty acid and glucose metabolism are tightly linked in a we- established and profoundly inportant interplay. This connection, together with the fact that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis reflects inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, suggested the possibility that regulation of fatty acid metabolism could prove to be a pivotal determinant in the control of cell growth. In 1993, the year in which the paper cited above was published, insight into the importance of growth factors and signal transduction pathways in cell cycle regulation was increasing rapidly, but metabolic and energetic aspects of cell proliferation had attracted relatively little attention. Despite this, the concept seemed inescapable that the two seemingly distinct and unrelated determinants — signal transduction and metabolism — were integrally linked.

Informazioni sull?autore

Robert K. Ockner, M.D., Professor of Medicine at the University of California, San Francisco, graduated from Pomona College and Harvard Medical School, and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital. He is former Director of the UCSF Division of Gastroenterology and the UCSF Liver Center, and served as Editor of Gastroenterology, Co-Editor of Progress in Liver Diseases, and Associate Editor of the Journal of Lipid Research. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins.