Interface Oral Health Science 2007

Since 2002, the Tohoku University Graduate School of Dentistry has proposed “Interface Oral Health Science” as a major theme for next-generation dental research. That theme is based on the innovative concept that healthy oral function is provided by biological and biomechanical harmony among three systems: (1) oral tissues including the teeth, mucosa, bones, and muscles (host); (2) parasitic microorganisms of the oral cavity (parasites); and (3) biomaterials. The concept posits that oral diseases such as dental caries, periodontal disease, and tempo- mandibular disorders should be interpreted as interface diseases that result from disruption of the intact interfaces among these systems. The uniqueness of this concept rests on the fact that it not only encompasses the entire ? eld of dentistry and dental care, but also expands the common ground shared with many other ? elds, including medicine, pharmaceutical science, agriculture, material science, and engineering. Our Graduate School of Dentistry aims to promote advances in dental research and to activate interdisciplinary research with related ? elds by putting interface oral health science into practice. On this basis we organized the First International Symposium for Interface Oral Health in February 2005, with productive discussions stimulated by two special lectures, three symposia, and poster presentations. A monograph titled Interface Oral Health Science that s- marized the contents of the symposium was published in the autumn of 2005 (International Congress Series 1284, Elsevier, Amsterdam). The Second International Symposium was the most recent.

Plenary lectures Possibility of bulk glassy and nanogranular alloys as biomedical materials Akihisa Inoue and Xin Min Wang Conversion of functions by nanosizing―from osteoconductivity to bone substitutional properties in apatite Fumio Watari, Atsuro Yokoyama, Michael Gelinsky, Wolfgang Pompe Symposium I: Anniversary symposium Stress and microbial diversity in the oral biofilm David Beighton Characterisation of the human oral microbiome and metagenome William G. Wade Novel functions of adhesins encoded by gingipain genes of Porphyromonas gingivalis Koji Nakayama Implication of immune interactions in bacterial virulence: is Porphyromonas gingivalis an “Invader” or “Stealth Element” in periodontal lesions? Hidetoshi Shimauchi and Tomohiko Ogawa Symposium II: Biomaterials (1), Novel dental biomaterials Multifunctional low-rigidity b-type Ti–Nb–Ta–Zr system alloys as Biomaterials Mitsuo Niinomi Study of in vivo bone tissue engineering Chongyun Bao, Hongyu Zhou, Wei Li, Yunfeng Li, Hongsong Fan, Jinfeng Yao, Yunmao Liao, and Xingdong Zhang Toughening of bioabsorbable polymer blend by microstructural modification Mitsugu Todo and Tetsuo Takayama Corrosion resistance and biocompatibility of a dental magnetic attachment Osamu Okuno and Yukyo Takada Symposium III: Biomaterials (2), Scaffold for oral tissue regeneration Developmental genetics of the dentition Wei-Yuan Yu and Paul Sharpe Involvement of PRIP, a new signaling molecule, in neuroscience and beyond oral health science Masato Hirata, Takashi Kanematsu, and Akiko Mizokami Biomaterials based on mineralised collagen―an artificial extracellular bone matrix Michael Gelinsky, Anne Bernhardt, Marlen Eckert, Thomas Hanke, Ulla König, Anja Lode, Antje Reinstorf, Corina Vater, Anja Walther, Atsuro Yokoyama, and FumioWatari Less response of osteocyte than osteoblast to mechanical force: implication of different focal adhesion formation Teruko Takano-Yamamoto, Hiroshi Kamioka, and Yasuyo Sugawara Section I: Biomechanical-biological interface Mechanical stretch inhibits chondrogenesis through ERK-1/2 phosphorylation in micromass culture Ichiro Takahashi, Fumie Terao, Taisuke Masuda, Yasuyuki Sasano, Osamu Suzuki and Teruko Takano-Yamamoto Development of mechanical strain cell culture system for mechanobiological analysis Taisuke Masuda, Ichiro Takahashi, Aritsune Matsui, Takahisa Anada, Fumihito Arai, Teruko Takano-Yamamoto, and Osamu Suzuki Regulation of osteoprotegerin and RANKL gene expression by Wnt/b-catenin and bone morphogenetic protein-2 in C2C12 cells Mari Sato, Aiko Nakashima, Masayuki Nashimoto, Yasutaka Yawaka, and Masato Tamura Application of electroporation to mandibular explant culture system for gene transfection Fumie Terao, Ichiro Takahashi, Hidetoshi Mitani, Naoto Haruyama, Osamu Suzuki, Yasuyuki Sasano, and Teruko Takano-Yamamoto Effects of initially light and gradually increasing force on orthodontic tooth movement Ryo Tomizuka, Hiroyasu Kanetaka, Yoshinaka Shimizu, Akihiro Suzuki, Sachiko Urayama, and Teruko Takano-Yamamoto Biomechanical effect of incisors’ traction using miniscrew implant Shota Yoshida, Koshi Sato, Toru Deguchi, Kazuhiko Kushima, Takashi Yamashiro, and Teruko Takano-Yamamoto Periodontal tissue activation by resonance vibration Makoto Nishimura, Mirei Chiba, Toshiro Ohashi, Masaaki Sato, and Kaoru Igarashi Mesenchymal stem cells in human wisdom tooth germs D. Nishihara, Y. Iwamatsu-Kobayashi, M. Hirata, K. Kindaichi, J. Kindaichi, and M. Komatsu Osteoblast apoptosis by compressive force and its signaling pathway Mirei Chiba, Yuko Goga, Aya Sato, and Kaoru Igarashi Effects of a selective cyclooxygenase-2 inhibitor, celecoxib, on osteopenia and increased bone