Introduction to Cellular Signal Transduction

Ari Sitaramayya

ISBN 10: 1461273706 / ISBN 13: 9781461273707

Editore: Birkhäuser Boston, 2012

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Druck auf Anfrage Neuware - Printed after ordering - Our understanding of biological communication has grown significantly during the past decade. The advances in knowledge about the chemical nature of signals and their corresponding reception by specialized cells have led to identification, characterization, purification, cloning, and expression of specific receptor molecules. While the earlier literature emphasized com partmentalized treatment of informational molecules and their interaction with receptors, the progress in the recent past has allowed cross-fertilization in the examination of the of actions and mechanisms of steroid and protein hormones and other messengers. Investigators now have an increased ap preciation of the multiple effects of specific hormones and of the diverse responses by receptor proteins to closely related ligands. The task of compil ing this enormous literature into a focused treatise was undertaken with the launching of the series Hormones in Health and Disease. This latest volume, An Introduction to Cellular Signal Transduction, complements the previous monographs in the series and brings to the fore recent developments in the field of biochemical communication. This volume combines discussions on the basic tenets of the signal transduction process and its relevance to health and disease. While various chapters provide exhaustive dissection of specific topics for researchers in the field, the book is also an excellent vehicle for introducing students and new investigators to the subject. The contributors of the chapters are active and accomplished scientists brought together on a common platform by the editor, Dr.

Codice articolo 9781461273707

Dati bibliografici

• Titolo: Introduction to Cellular Signal Transduction
• Editore: Birkhäuser Boston
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 1461273706
• ISBN 13: 9781461273707
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 235 L x 155 A x 18 P (millimetri) 235 millimetri di larghezza per 155 millimetri di altezza per 18 millimetri di profondità
• Peso: 499 grammi

Descrizione articolo

Riassunto

This book is designed for senior undergraduate/graduate level students interested in a basic understanding of the major participants in the cellular Signal Transductions pathways. The book is suitable for an introductory course in Signal Transduction, as well as for self-study and review. It is recommended for biology and medical students, as well as for other science majors interested in interdisciplinary research efforts, e.g. in pharmaceuticals, biochemistry and bioengineering.

Contenuti

Foreword * Contributors * Overview by Ari Sitaramayya * Cell Surface Receptors: Mechanisms of Signaling and Inactivation * Heterotrimeric G-proteins: Structure, Regulation and Signaling Mechanisms * Ras and Rho-Related Small Molecular Weight G-proteins: Structure and Signaling Mechanisms * Cyclic Nucleotides: Synthesis by Adenylyl and Guanylyl Cyclases * Phospholipases: Generation of Lipid-Derived Second Messengers * Cyclic Nucleotide Phosphodiesterases: Structure and Functional Aspects * Nitric Oxide: Synthesis and Intracellular Actions * Ionic Channels Mediating Sensory Transduction * Bits for an Organic Microprocessor: Protein Phosphorylation/Dephosphorylation * Defects in Signal Transduction Proteins Leading to Disease * Intracellular Messengers in Drug Addiction * Keyword Index