Riassunto
International Symposia sponsored by ClBA Basle have been held once a year since 1959 in various European countries. In con trast to the many scientific meetings organised by the ClBA FOUN DATION either at its headquarters in London or occasionally abroad, the subjects dealt with at these International Symposia have con cerned problems more directly related to ClBA'S own research work in the pharmaceutical field. The various topics covered up to the present reflect the far-reaching interests and the wide spread activities that a pharmaceutical enterprise develops in quite diverse fields of chemical, biological, and medical research, and to which the ba.sic approach is an increasingly important prerequisite for the development of a new and useful therapeutic agent. Iron metabolism came into the sphere of interest in connection with CIBA'S research on antibiotics and related natural products containing iron, substances which act in their metal-free form as strong and specific chelating agents. Of course, these observations, interesting though they are, would not in themselves have justi fied a symposium. It seemed, however, useful to examine the new results from a wider perspective and to attempt to relate them to present-day knowledge of iron metabolism in general its physiology, its pathology, and therapeutic aspects. The success of a scientific symposium depends on the concep tion of the programme and the selection of the participants.
Contenuti
Iron metabolism, past, present, and future Introduction.- Biochemistry of iron.- The function of iron in biochemistry.- Discussion: Eichhorn, London, Rittenberg, Schubert.- Incorporation of iron in the haem moiety of chromoproteins.- Discussion: Gajdos, Kruh, London, Moeschlin. Najean, Yoshikawa..- Ferritin and haemosiderin.- Discussion: Bearn, Beutler, Eichhorn, Gajdos, Harrison, Kruh,Najean, Saadi, Wöhler.- Some observations on transferring.- Discussion: Bearn, Chatterjea, Katz, Kruh, Moeschlin, Saadi, Ventura.- Iron-containing compounds in micro-organisms.- General Discussion: Introduction by I. M. London.- Physiology of iron.- Digestive absorption of iron.- Discussion: Beutler, Bothwell, Brick, Callender, J.-C. Dreyfus, Finch, Gajdos, Hallberg, Kruh, Moeschlin, Moore, Najean, Salera, Sherlock, Undritz, Ventura, Wöhler.- The role of transferrin in the transport of iron into the developing red cell.- Discussion:J.-C. Dreyfus, Finch, Katz, London, Najean, Peters, Salera, Schapira, Tubiana.- Mechanisms of iron storage.- Discussion: Chatterjea, Sturgeon.- Iron kinetics.- Discussion: Beutler, Chatterjea, Figueroa, Finch, Katz, Kruh, Najean, Pollycove, Saadi, Tubiana, Vannotti.- General Discussion: Introduction by U. Salera.- Iron deficiency.- Experimental hyposiderosis.- Human hyposideraemia.- Discussion: Beutler, Eichhorn, Finch, Gajdos, Hallberg, Heilmeyer, Morgan, Mouriquand, Undritz, Witts.- Some aspects of iron-deficiency anaemia in India.- Iron nutrition.- Tissue effects of iron deficiency.- Discussion: Beutler, Brick, Callender, Chatterjea, Hallberg, Moeschlin, Moore, Najean, Pollycove, Salera, Schapira, Tubiana, Ventura.- Neuro-endocrine control of iron metabolism.- Discussion: Katz, Saadi, Schäfer, Schapira.- General Discussion: Introduction by A. Vannotti.- Iron overload.- The metabolism of iron in haemochromatosis.- Surcharge ferrique dans les cirrhoses (à l’exclusion de l’hémochromatose idiopathique).- Discussion: Albahary, Bearn, Bothwell, Brick, Caroli, J.-C. Dreyfus, Figueroa, Frick, Katz, Moeschlin, Tubiana, Vannotti, Ventura, Verloop.- Post-transfusional haemosiderosis.- Discussion: Brick, Callender, Cleton, J.-C. Dreyfus, Figueroa, Najean, Pollycove, Sherlock.- Iron overload in the Bantu.- Discussion: Albahary, Bothwell, Brick, Mouriquand, Pollycove, Saadi.- Hereditary hypochromic hypersideraemic anaemia.- Discussion: Beutler, Caroli, Gajdos, Heilmeyer, Pollycove, Sturgeon, Undritz, Verloop.- General Discussion: Introduction by Sheila Sherlock.- Therapeutics.- Oral treatment of iron deficiency.- Parenteral treatment of iron deficiency.- Discussion: Figueroa, Gross, Moeschlin, Najean, Pollycove, Salera, Schapira, Undritz, Verloop, Witts.- Physiopathologic mechanisms of iron excretion.- Discussion: Beutler, Finch, Moore, Najean, Peters, Pollycove, Sturgeon, Tubiana.- The chemical basis of chelation.- Discussion: Cleton, Eichhorn, Peters, Prelog, Schubert.- General Discussion: Introduction by B. Dreyfus.- A pharmacological comparison of the binding of iron and other metals.- Discussion: Cleton, Figueroa, Hallberg, Heilmeyer, Najean, Peters, Schubert, Tripod, Vannotti.- Treatment of primary and secondary haemochromatosis and acute iron poisoning with a new, potent iron-eliminating agent (desferrioxamine B).- The treatment of haemochromatosis with desferrioxamine.- Evaluation of trisodium calcium diethylene-triamine penta-acetate in hemochromatosis and transfusion hemosiderosis.- General Discussion: Introduction by C. Albahary.- Summing up.- List of authors.
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