Kinase Screening and Profiling : Methods and Protocols

Said A. Goueli

ISBN 10: 1493930729 / ISBN 13: 9781493930722

Editore: Springer New York, Springer US, 2015

Riguardo questo articolo

Druck auf Anfrage Neuware - Printed after ordering - This volume focuses on screening and profiling kinase inhibitors or activators. Chapters in this book cover several facets of the drug discovery processes starting with target identification, and assay development and screening chemical libraries for hit identification and lead optimization. The profiling portion of Kinase Screening and Profiling: Methods and Protocols discusses several strategies and techniques that are required to minimize off target hits and reduce cellular toxicities that are caused by liability kinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Timely and authoritative, Kinase Screening and Profiling: Methods and Protocols, will benefit scientists and researchers who are interested in exploring the role of kinases in academic, as well as pharmaceutical research.

Codice articolo 9781493930722

Dati bibliografici

• Titolo: Kinase Screening and Profiling : Methods and Protocols
• Editore: Springer New York, Springer US
• Data di pubblicazione: 2015
• Lingua: Inglese
• ISBN 10: 1493930729
• ISBN 13: 9781493930722
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 260 L x 183 A x 18 P (millimetri) 260 millimetri di larghezza per 183 millimetri di altezza per 18 millimetri di profondità
• Peso: 702 grammi

Descrizione articolo

Riassunto

This volume focuses on screening and profiling kinase inhibitors or activators. Chapters in this book cover several facets of the drug discovery processes starting with target identification, and assay development and screening chemical libraries for hit identification and lead optimization. The profiling portion of Kinase Screening and Profiling: Methods and Protocols discusses several strategies and techniques that are required to minimize off target hits and reduce cellular toxicities that are caused by liability kinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Timely and authoritative, Kinase Screening and Profiling: Methods and Protocols, will benefit scientists and researchers who are interested in exploring the role of kinases in academic, as well as pharmaceutical research.