Malignant Lymphomas of the Nervous System

More than 150 years have passed since involvement of the nervous system in leukemia was first reported by BURNS, while the possibility of the primary brain tumor derived from the lymphoreticular tissue was recognized much later. BAILEY in 1929 described such neoplasms under the term perithelial sarcoma. Later these tumors of the nervous system have been variously designated as "Perivascular of perithelial sarcomas, reticulum cell sarcomas or microgliomas", as controversy has evolved and still exists on the definition of this group of neoplasms and on the nature of their cells of origin. Much of the unfortunate confusion concerning the neoplastic lesions attributed to "microglia" and other derivations of the RE system arose because their close relationship to extra­ neural cells has been ignored. On the other hand, communication in the field of malignant lymphomas has become increasingly difficult because of the termino­ logic maze and conceptual diversities of traditional morphological classifica­ tions that have limited valid comparisons. Although at present we are still far from a precise recognition of the basic features of lymphoproliferative processes and from a fairly general agreement on the terminology of non-Hodgkin lymphomas, there is encouraging evidence recently of some enlightment on the nature of tumor cells that provides the basis for a reasonable and generally acceptable lymphoma classification.

Morphology and Classification of Malignant Lymphomas and So-called Reticulosis.- Ultrastructural Features of Human Lymphomas.- Morphological Classification of Malignant Lymphomas: Ultrastructural, Cytochemical and Immunological Results.- Classification of Malignant Lymphomas by Means of Membrane Markers.- Differentiation of Lymphoid Cells of the Cell Series According to Membrane and Cytoplasmic Determinants.- Studies of the Mechanism of Growth Promotion of Lymphoma Cells by 2-Mercaptoethanol in vitro.- Myxovirus-Like Particles in Cells of American Burkitt’s-Type Lymphoma.- Acid Phosphatase of Azurophilic Granules of C3HST4 Lymphoma.- The Fine Structure of the Lymphocyte Nucleus Under Conditions of Phytohaemagglutinin Stimulation.- Studies on Lymphocyte Sensitization to Encephalitogenic Protein in Tumor Patients.- Malignant Lymphomas of the Nervous System.- Lymphoreticular Proliferative Disorders of the CNS and Other Organs: Analogies and Differences.- Neoplastic Involvement of the CNS in Generalized Lymphomas.- Primary Lymphoreticuloses of the Nervous System in Animals.- Pathology of Primary Reticulum Cell Sarcoma of the Human Central Nervous System.- Primary Malignant Lymphomas of the Central Nervous System in Man.- Primary Lymphomas of the Central Nervous System; in vitro Culture Observations.- Primary and Borderline Brain Lymphosarcoma: A Neuropathological Review of Nine Cases.- Microglioma and/or Reticulosarcoma of the Nervous System.- The Classification of Microgliomatosis with Particular Reference to Diffuse Microgliomatosis.- Patterns of Proliferation in Cerebral Lymphoreticular Tumours.- “Malignant Lymphoma” of the Brain Following Renal Transplantation.- Human and Experimental Reticulum Cell Sarcoma (Microglioma) of the Nervous System.- A Comparison of the Fine Structure of Malignant Lymphoma and Other Neoplasms in the Brain.- Fine Structure of Primary Reticulum Cell Sarcoma of the Brain.- Ultrastructural Study of Two Central Nervous System Lymphomas.- Primary Cerebral Reticulosis and Plasma Cell Differentiation.- Nuclear Characteristics of Malignant Lymphoma in the Brain.- The Ultrastructure of Reticulin.- Certain Notable Clinical Attributes of the Histiocytic Sarcomas of the Central Nervous System.- Differential Diagnostic Aspects in Malignant Lymphomas Involving the Central Nervous System.- Cytology of the Cerebrospinal Fluid in Patients with Hodgkin’s Disease or Malignant Lymphoma.- Light- and Electronmicro-scopic Studies in Hemoblastosis with CNS-Disorder.- Electron Microscopy of Lymphocytic Leukaemia Cells in the Cerebrospinal Fluid.- Family Studies in Cases with Malignant Lymphomas.- Clinical and Pathological Studies in a Case of Reticulum Cell Sarcoma.- Lymphoblastic Extramedullary Spinal Tumor During Remission of Acute Lymphoblastic Leukaemie.- Radiotherapy of Malignant Lymphomas.- Chemotherapy of Malignant Lymphomas.- Immunotherapy of Malignant Disease in Man.- Meningeal Localisation of Acute Leukaemias.- Prevention of Meningeal Leukaemia and Relapses by Cranial Irradiation and Intrathecal MTX in Acute Lymphatic Leukaemia.- Atypical Progressive Multifocal Leuko-encephalopathy with Plasma-Cell Infiltrates.- Leukoencephalopathy Following Combines Therapy of Central Nervous System Leukemia and Lymphoma.- Diffuse Reticulosis with Leukomalacia.- Unusual Infections of the Nervous System in Malignant Lymphomas.- SSPE-like Inclusion Body Disorder in Treated Childhood Leukemia.- The Ultrastructure of Normal and Reactive Microglia.- EM Findings on the Source of Reactive Microglia on the Mammalian Brain.- Experimental Studies on Kinetics and Functions of Monuclear Phagozytes of the Central Nervous System.- Origin of Brain Macrophages and the Nature of the So-Called Microglia.- The Relationship Between Microglia and Brain Macrophages. Experimental Investigations.- Conclusions.