The Mammalian Cochlear Nuclei : Organization and Function

Miguel A. Merchán

ISBN 10: 1461362733 / ISBN 13: 9781461362739

Editore: Springer US, 2012

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Druck auf Anfrage Neuware - Printed after ordering - The presence of sophisticated auditory processing in mammals has permitted perhaps the most significant evolutionary development in humans: that of language. An understanding of the neural basis of hearing is thus a starting point for elucidating the mechanisms that are essential to human communication. The cochlear nucleus is the first region of the brain to receive input from the inner ear and is therefore the earliest stage in the central nervous system at which auditory signals are processed for distribution to higher centers. Clarifying its role in the central auditory pathway is crucial to our knowledge of how the brain deals with complex stimuli such as speech, and is also essential for understanding the central effects of peripheral sensorineural hearing loss caused by, for example, aging, ototoxic drugs, and noise. Ambitious new developments to assist people with total sensorineural deafness, including both cochlear and cochleus nuclear implants, require a detailed knowledge of the neural signals received by the brainstem and how these are processed. Recently, many new data have been obtained on the structure and function of the cochlear nucleus utilizing combinations of anatomical, physiological, pharmacological and molecular biological procedures. Approaches such as intracellular dye-filling of physiologically identified neurons, localization of classical neurotransmitters, peptides, receptors and special proteins, or gene expression have opened the door to novel morphofunctional correlations.

Codice articolo 9781461362739

Dati bibliografici

• Titolo: The Mammalian Cochlear Nuclei : Organization and Function
• Editore: Springer US
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 1461362733
• ISBN 13: 9781461362739
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 254 L x 178 A x 30 P (millimetri) 254 millimetri di larghezza per 178 millimetri di altezza per 30 millimetri di profondità
• Peso: 1032 grammi

Descrizione articolo

Riassunto

The presence of sophisticated auditory processing in mammals has permitted perhaps the most significant evolutionary development in humans: that of language. An understanding of the neural basis of hearing is thus a starting point for elucidating the mechanisms that are essential to human communication. The cochlear nucleus is the first region of the brain to receive input from the inner ear and is therefore the earliest stage in the central nervous system at which auditory signals are processed for distribution to higher centers. Clarifying its role in the central auditory pathway is crucial to our knowledge of how the brain deals with complex stimuli such as speech, and is also essential for understanding the central effects of peripheral sensorineural hearing loss caused by, for example, aging, ototoxic drugs, and noise. Ambitious new developments to assist people with total sensorineural deafness, including both cochlear and cochleus nuclear implants, require a detailed knowledge of the neural signals received by the brainstem and how these are processed. Recently, many new data have been obtained on the structure and function of the cochlear nucleus utilizing combinations of anatomical, physiological, pharmacological and molecular biological procedures. Approaches such as intracellular dye-filling of physiologically identified neurons, localization of classical neurotransmitters, peptides, receptors and special proteins, or gene expression have opened the door to novel morphofunctional correlations.

Contenuti

Developmental Issues: Postnatal Development of Auditory Nerve Projections to the Cochlear Nucleus in Monodelphis Domestica; F.H. Willard. Primary Inputs: Anatomical and Physiological Studies of Type I and Type II Spiral Ganglion Neurons; M.C. Brown. Intrinsic Connections: The Synaptic Organization of the Ventral Cochlear Nucleus of the Cat; N.B. Cant. Descending Projections: Non-Cochlear Projections to the Ventral Cochlear Nucleus; R.L. Saint Marie, et al. Neurotransmitters of the Cochlear Nucleus: Localizing Putative Excitatory Endings in the Cochlear Nucleus by Quantative Immunocytochemistry; J.M. Juiz, et al. Projections and Response Properties of Cochlear Nucleus Neurons: The Cochlear Root Neurons in the Rat, Mouse, and Gerbil; D.E. López, et al. Computer Modelling of the Cochlear Nucleus: Regularity of Discharge Constrains Models of Ventral Cochlear Nucleus Bushy Cells; E.D. Young, et al. 33 addition articles. Index.