This book contains a collection of quantitative procedures in common use in pharmacology and related disciplines. It is intended for students and researchers in all fields who work with drugs. Many physicians, especially those concerned with clinical pharmacology, will also find much that is useful. The procedures included may be considered "core" since they are generally applicable to all classes of drugs. Some of the procedures deal with statistics and, hence, have even wider application. In this new edition we have increased the number of procedures from 33 (in the first edition) to 48. Other procedures have been revised and expanded. Yet the basic philosophy of this new edition remains unchanged from the first. That is, the pharmacologic basis of each procedure is presented, along with the necessary formulas and one or more worked examples. An associated computer program is included for each procedure and its use is illustrated with the same worked example used in the text. The discussions of theory and the sample computations are brief and self-contained, so that all computations can be made with the aid of a pocket calculator and the statistical tables contained in Appendix A. Yet it is realized that the proliferation of lower-priced microcom� puters is likely to mean that more and more readers will utilize a computer for most calculations. Accordingly, we have modified the format of the book to facilitate computer usage.

Contenuti

1. Dosage and Concentration: Drug Stock Solutions.- 2. Mean, Standard Deviation and Confidence Limits.- 3. Linear Regression I.- 4. Linear Regression II: Lines through Origin.- 5. Analysis of the Regression Line.- 6. Parallel Lines I: Test for Parallelism.- 7. Parallel Lines II: Construction of Parallel Lines.- 8. Graded Dose-Response.- 9. Quantal Dose-Response: Probits.- 10. Relative Potency I.- 11. Relative Potency II: Statistical Analysis.- 12. Dissociation Constant I: Agonists.- 13. Dissociation Constant II: Partial Agonists.- 14. Dissociation Constant III: Perturbation Methods.- 15. pA2 Analysis I: Schild Plot.- 16. pA2 Analysis II: Time-Dependent Method.- 17. pA2 Analysis III: Constrained Plot.- 18. Enzyme Kinetics I: Michaelis-Menten Equation.- 19. Enzyme Kinetics II: Competitive Inhibition.- 20. Enzyme Kinetics III: Noncompetitive Inhibition.- 21. First-Order Drug Decay.- 22. Scatchard Plot.- 23. Henderson-Hasselbalch Equation.- 24. Exponential Growth and Decay.- 25. Area under a Curve: Trapezoidal and Simpson’s Rules.- 26. Pharmacokinetics I: Constant Infusion with First-Order Elimination.- 27. Pharmacokinetics II: Multiple Intravenous Injections.- 28. Pharmacokinetics III: Volume of Distribution.- 29. Pharmacokinetics IV: Plasma Concentration-Time Data.- 30. Pharmacokinetics V: Renal Clearance.- 31. Pharmacokinetics VI: Renal Excretion Data Following Intravenous Administration.- 32. Pharmacokinetics VII: Multiple Dosing from Absorptive Site.- 33. Analysis of Variance I: One-Way.- 34. Analysis of Variance II: Two-Way, Single Observation.- 35. Analysis of Variance III: Two-Way, with Replication.- 36. Newman-Keuls Test.- 37. Duncan Multiple Range Test.- 38. Least Significant Difference Test.- 39. t-Test I: Grouped Data.- 40. t-Test II: Paired Data.- 41. Ratio of Means.- 42. Chi-Square Test.- 43. Proportions: Confidence Limits.- 44. Dunnett’s Test (Comparison with a Control).- 45. Mann-Whitney Test.- 46. Litchfield and Wilcoxon I: Confidence Limits of ED50.- 47. Litchfield and Wilcoxon II.- 48. Differential Equations.- Appendix A: Mathematical Tables.- Appendix B: PHARM/PCS User’s Guide.

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