Metals in Bone

In 1980 the Internal Emitters Committee of EULEP organised a symposium in Rotterdam on Bone and Bone Seeking Radionu cI ides: Their Physiology, Dosimetry and Effects. The speakers for this meeting, mostly from EULEP associ­ ated laboratories, were chosen to review this field of scientific research mostly for the benefit of interested scientists who were not actively researching with bone­ seeking radionuclides. This meeting was a success and its proceedings were subsequently published in the form of a book by the Commission of the European Communities, reflecting the great importance that both EULEP and the Radiologi­ cal Protection Programme of the Commission of the European Communities attaches to the study of radionuclides that deposit in bone. The Metals in Bone symposium in Angers was intended to serve a different function from that of the meeting held in Rotterdam in that, while these proceed­ ings will certainly be of interest to non-involved scientists, the meeting was intended to be of most benefit to those actively researching the metabolism and effects of bone-seeking metals. Moreover, in an attempt to increase the value of its discussions and the number of interested and participating scientists, the remit of the meeting was broader and set to include papers on stable as well as radioactive metals.

1 Bone Mineralization and Turnover.- 1 Receptor Molecules, Coprecipitation and Ion Exchange Processes in the Deposition of Metal Ions in Bone.- 2 Localization of Technetium-99m in Bone.- 3 The Pattern of Calcium Deposition in Rat Bone as Demonstrated by Calcein Labeling.- 2 Metals and the Bone Marrow.- 4 Iron Metabolism in the Bone Marrow.- 5 The Study of Damage to Bone Marrow Cells as a Biological Dosimeter after Contamination with Osteotropic ? Emitters.- 6 Functional Damage to Bone Marrow Fibroblasts after Contamination with Americium-241.- 7 The Release of Transportable Plutonium from Macrophages: The Effects of Dietary Iron.- 3 Alkaline Earth Metals and Bone.- 8 Long-term Retention of Radium in Female Former Dial Workers.- 9 Strontium-90 Content in Human Bone in West German Residents.- 10 Long-term Retention and Turnover Studies with 85Sr.- 11 Dynamics of Lifespan Strontium-90 Distribution in Beagles with Uniformly Labelled Skeletons Acquired by Radionuclide Ingestion from In Utero to Adulthood.- 12 Effect of Stable Strontium on Bone Metabolism in Rats.- 13 The Distribution of Radium and Plutonium in Human Bone.- 14 Skeletal Distribution of Stable Strontium and its Incorporation into Bone Mineral In Vivo.- 15 Convolution Analysis Applied to Skeletal Uptake of 47Ca and 85Sr Measured by External Counting.- 4 Actinide Metals and Bone.- 16 Toxicity of Plutonium and Americium: Relationship of Bone Composition to Location of 226Ra, 239Pu and 241Am-Induced Bone Sarcomas.- 17 Initial Deposition Pattern of Actinides 91 to 96 in the Skeleton of the Rat.- 18 Pu Microdistribution Study in Cortical Bones of Beagle Dogs.- 19 Removal of Plutonium and Americium from Various Parts of Rat Skeleton by Oral Zn-DTPA.- 20 The Retention of Plutonium in Human Bone: A Reconnaissance.- 21 Distribution of Plutonium-239 and Americium-241 in the Human Skeleton.- 22 Uranium, Thorium and Plutonium in Bones from the General Population of the United States.- 23 Metabolic Behaviour of Plutonium in Mice.- 5 Microdosimetry of Radionuclides in Bone.- 24 Microdosimetry of Bone: Implications in Radiological Protection.- 25 Localized Alpha-Dosimetry for Cancer Induction Studies.- 26 The Dosimetry of Plutonium-239 in Bones of the Female Mouse and its Relationship to Observed Effects.- 27 A New Dosimetric Model for Bone Surface Seeking Radionuclides in the Skeleton.- 28 Variation of Radiation Exposure Due to the Administration of Iron-59 in Patients with Different Diseases.- 6 Pathology of Metals in Bone.- 29 Pathogenesis of Radionuclide-Induced Bone Tumors.- 30 Effects of Iron Overload on Bone Remodelling in Pigs.- 31 Skeletal Lesions from Inhaled Plutonium in Beagles.- 32 The Induction, by 239Pu, of Myeloid Leukaemia and Osteosarcoma in Female CBA Mice (Interim Results).- 33 The Effect of Manganese Ingestion, Phosphate Depletion and Starvation on the Epiphyseal Growth Plate.- 34 Influence of External Irradiation on Sr Deposit in Bone.- 7 Trace Metals in Bone.- 35 The Variation with Flow-Rate of the Extraction of Bone-Seeking Tracers in Recirculation Experiments.- 36 Chromium Exchange in the Rat Skeleton.- 37 Historical Changes of Trace Metals in Human Bones from France.- 38 Some Aspects of Lead Uptake by the Bones.- 39 Lead Accumulation in Rat’s Bone in Relation to Age.- 40 The Autoradiographic Method for Lead-210 Quantitative Determination.- 41 Microdistribution of Lead-210 in the Rabbit’s Osseous Tissue.- 42 Lead in Human Bones and Teeth at the Part-Per-Million Level.- 43 Comparative Study of the Chemical Behaviour of Trace Elements in Dental Enamel.- 8 Metabolism and Effects of Stable Elements.- 44 Ultrastructural Study of Bone and Small Intestine Cells in Lead-Intoxicated Rats.- 45 Aluminium Fluoride Inter-Relationships in Renal Failure.- 46 Evaluation of Different Techniques Used to Determine Aluminium in Patients with Chronic Renal Failure.- 47 Evaluation of the Role of Aluminium on the Bone Histomorphometry of Uremic Patients.- 48 In Vitro Modelling of the Role of Aluminium in Inducing Osteomalacia in Dialysis Patients.- 49 Is Osteomalacia of Renal Osteodystrophy Due to Al Intoxication? An Experimental Study in the Rat.