Model-Based Process Prediction for Predictive-Reactive Scheduling in Automated Stem Cell Production

Lingua: inglese

Editore: Apprimus Verlag

398555059X / 9783985550593

Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

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nach der Bestellung gedruckt Neuware - Printed after ordering - Mesenchymal stem cells are highly relevant candidates for cell-based therapies. Since the production is complex and prone to high batch-to-batch variations, processes are increasingly automated. The StemCellDiscovery is a robot-assisted laboratory that allows end-to-end automation of stem cell cultivation processes in small-scale and parallel. Since the investment costs for such systems are high, the return of investment has to be fast to be profitable. Thus, an efficient production is crucial. This thesis investigates whether model-based, predictive-reactive scheduling is suited to increase efficiency in automated production of stem cells. Since the stem cell culture processes can be subject to sudden changes, robotic cultivation systems to date rely mainly on reactive scheduling approaches. While reactive schedulers ensure robust operation, they are not globally optimized and thus often inferior to predictive approaches. This can cause inefficient culture handling, suboptimal harvesting times and unnecessary consumption of system resources. To avoid this, the approach presented here utilizes a mathematical model to extrapolate the growth curves of mesenchymal stem cell cultures based on previous microscopic confluence measurements. This thesis presents a proof-of-concept for a predictive scheduler for generation of optimized schedules based on the model's confluence prediction. The predictive scheduler is complemented by a schedule repair heuristic designed to absorb process disruptions. Both elements are optimized and tested using a detailed simulation model of the production environment. The application of the resulting predictive-reactive scheduling approach is demonstrated by benchmarking against the reactive state of the art.

Codice articolo 9783985550593

Dati bibliografici

Titolo
Model-Based Process Prediction for Predictive-Reactive Scheduling in Automated Stem Cell Production
Autore
Jelena Katherina Ochs
Editore
Apprimus Verlag
Condizione
Neu
Rilegatura
Taschenbuch
Lingua
inglese
ISBN 10
398555059X
ISBN 13
9783985550593
Peso dell'articolo
281 grammi
Dimensioni
210x148x12 mm

AHA-BUCH GmbH

Einbeck, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 30 a 40 giorni lavorativiDa 7 a 14 giorni lavorativi
Primo articoloEUR 61,41EUR 71,41
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